Background: Decreased cardiac contractility has been noticed in cirrhosis, however the mechanisms that provoke and preserve cardiac dysfunction will not be fully understood.
Intention of the examine: We check the speculation that cirrhotic cardiomyopathy is expounded to deterioration of myocardial contractility on account of alterations in calcium-handling proteins expression. As well as, we evaluated whether or not cardiac pro-inflammatory cytokine ranges are related to this course of.
Strategies: Cirrhosis was induced by thioacetamide (TAA, 100 mg/kg/i.p., twice weekly for eight weeks). The myocardial efficiency was evaluated in remoted left ventricle papillary muscle mass beneath basal situations and after inotropic problem. The cardiac calcium dealing with protein expression was detected by Western blotting. Cardiac TNF-α and IL-6 ranges had been measured by ELISA.
Outcomes: Thioacetamide induced liver cirrhosis, which was related to cirrhotic cardiomyopathy characterised by in vivo left ventricular diastolic and systolic dysfunction in addition to cardiac hypertrophy. In vitro baseline myocardial contractility was decrease in cirrhosis. Additionally, myocardial responsiveness to post-rest contraction stimulus was declined. Protein expression for RYR2, SERCA2, NCX, pPBL Ser16 and L-type calcium channel was quantitatively unchanged; nonetheless, pPBL Thr17 was considerably decrease whereas IL-6 was larger.
Conclusions: Our examine demonstrates that cirrhotic cardiomyopathy is related to decreased cardiac contractility with alteration of phospholamban phosphorylation in affiliation with larger cardiac pro-inflammatory IL-6 ranges. These findings offered molecular and practical insights concerning the results of liver cirrhosis on cardiac operate.
Nucleolin regulates 14-3-3ζ mRNA and promotes cofilin phosphorylation to induce tunneling nanotube formation
Tunneling nanotubes (TNTs) mediate intercellular communication between animal cells in well being and illness, however the mechanisms of their biogenesis and performance are poorly understood. Right here we report that the RNA-binding protein (RBP) nucleolin, which interacts with the identified TNT-inducing protein MSec, is crucial for TNT formation in mammalian cells. Nucleolin, by way of its RNA-binding domains (RBDs), binds to and maintains the cytosolic ranges of 14-3-3ζ mRNA, and is, subsequently, required for TNT formation. A particular area of the three’-untranslated area (UTR) of the 14-3-3ζ mRNA is more likely to be concerned in its regulation by nucleolin. Purposeful complementation experiments counsel that nucleolin and 14-3-3ζ kind a linear signaling axis that promotes the phosphorylation and inactivation of the F-actin depolymerization issue cofilin to induce TNT formation.
MSec additionally equally inactivates cofilin, however potentiates TNT formation impartial of the nucleolin-14-3-3ζ axis, regardless of biochemically interacting with each proteins. We present that 14-3-3ζ and nucleolin are required for the formation of TNTs between major mouse neurons and astrocytes and in a number of different mammalian cell varieties. We additionally report that the Caenorhabditis elegans orthologs of 14-3-3ζ and MSec regulate the dimensions and structure of the TNT-like mobile protrusions of the distal tip cell (DTC), the germline stem cell area of interest within the gonad. Our examine demonstrates a novel and probably conserved mRNA-guided mechanism of TNT formation by way of the upkeep of mobile 14-3-3ζ mRNA ranges by the RBP nucleolin.
The retinoblastoma tumour suppressor protein (RB) performs an necessary function in organic processes reminiscent of cell cycle management, DNA harm restore, epigenetic regulation, and genome stability. The canonical mannequin of RB regulation is that cyclin-CDKs phosphorylate, and render RB inactive in late G1/S, selling entry into S section. Not too long ago, mono-phosphorylated RB species had been described to have distinct cell-cycle impartial capabilities, suggesting {that a} phosphorylation code dictates range of RB operate. Nevertheless, a biologically related, practical function of RB phosphorylation at non-CDK websites has remained elusive.
HspB5/αB-crystallin phosphorylation at S45 and S59 is crucial for defense of the dendritic tree of rat hippocampal neurons
Rarefaction of the dendritic tree resulting in neuronal dysfunction is a trademark of many neurodegenerative ailments and we’ve proven beforehand that warmth shock protein B5 (HspB5)/αB-crystallin is ready to enhance dendritic complexity in vitro. The purpose of this examine was to research if this impact can be current in vivo, if HspB5 can counteract dendritic rarefaction beneath pathophysiological situations and the impression of phosphorylation of HspB5 on this course of. HspB5 and eight mutants inhibiting or mimicking phosphorylation on the three phosphorylation websites serine (S)19, S45 and S59 had been overexpressed in cultured rat hippocampal neurons with subsequent investigation of the complexity of the dendritic tree.
Sholl evaluation revealed vital larger complexity of the dendritic tree after overexpression of wildtype HspB5 and the mutant HspB5-AEE. All different mutants confirmed no or minor results. For in vivo investigation in utero electroporation of mouse embryos was utilized. At embryonal day E15.5 the respective plasmids had been injected, cornu ammonis 1 (CA1) pyramidal cells transfected by electroporation and their basal dendritic tree analyzed at postnatal day P15. In vivo, HspB5 and HspB5-AEE led to a rise of whole dendritic size in addition to the next complexity.
Histone H3 Methylation Antibody Panel Pack II – Repression Genes |
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| C10003 | EpiGentek |
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Histone H3 Methylation Antibody Panel Pack III – Active Genes |
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| C10004 | EpiGentek |
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Histone H3K4 Methylation Antibody Panel Pack |
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| C10005 | EpiGentek |
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Histone H3K9 Methylation Antibody Panel Pack |
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| C10006 | EpiGentek |
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Histone H3K27 Methylation Antibody Panel Pack |
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| C10007 | EpiGentek |
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Histone H3K36 Methylation Antibody Panel Pack |
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| C10008 | EpiGentek |
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Histone H3K79 Methylation Antibody Panel Pack |
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| C10009 | EpiGentek |
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Histone H3 Acetylation Antibody Panel Pack I |
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| C10010 | EpiGentek |
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Histone H3 Acetylation Antibody Panel Pack II |
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| C10011 | EpiGentek |
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Histone H4K20 Methylation Antibody Panel Pack |
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| C10012 | EpiGentek |
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Histone H4 Acetylation Antibody Panel Pack |
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| C10013 | EpiGentek |
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Histone H3 Phosphorylation Antibody Panel Pack |
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| C10014 | EpiGentek |
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Histone H3R2 Methylation Antibody Panel Pack |
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| C10015 | EpiGentek |
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Histone H3R8 Methylation Antibody Panel Pack |
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| C10016 | EpiGentek |
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Histone H3R17 Methylation Antibody Panel Pack |
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| C10017 | EpiGentek |
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Histone H3R26 Methylation Antibody Panel Pack |
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| C10018 | EpiGentek |
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Histone H4R3 Methylation Antibody Panel Pack |
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| C10019 | EpiGentek |
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DNMT3A Protein |
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| E11000 | EpiGentek |
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TET1 Protein (Active) |
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| E12002 | EpiGentek |
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DNMT3B Protein |
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| E14000 | EpiGentek |
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DNMT1 Protein |
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| E15000 | EpiGentek |
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HDAC1 Protein |
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| E24002 | EpiGentek |
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HDAC10 Protein |
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| E24003 | EpiGentek |
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HDAC11 Protein |
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| E24004 | EpiGentek |
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HDAC2 Protein |
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| E24005 | EpiGentek |
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HDAC3 Protein |
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| E24006 | EpiGentek |
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HDAC4 Protein |
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| E24007 | EpiGentek |
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HDAC5 Protein |
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| E24008 | EpiGentek |
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HDAC6 Protein |
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| E24009 | EpiGentek |
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HDAC7 Protein |
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| E24010 | EpiGentek |
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HDAC8 Protein |
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| E24011 | EpiGentek |
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HDAC9 Protein |
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| E24012 | EpiGentek |
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H3F3A Protein |
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| E35003 | EpiGentek |
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H4 Protein |
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| E35005 | EpiGentek |
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SOD1 Protein |
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| E70000 | EpiGentek |
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Goat Anti-Rabbit Secondary Antibody, Biotin Conjugated |
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| A12001 | EpiGentek |
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Goat Anti-Rat Secondary Antibody, Biotin Conjugated |
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| A12002 | EpiGentek |
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HRP-Goat Anti-Mouse Secondary Antibody |
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| A12003 | EpiGentek |
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HRP-Goat Anti-Rabbit Secondary Antibody |
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| A12004 | EpiGentek |
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EpiMag HT (96-Well) Magnetic Separator |
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| Q10002 | EpiGentek |
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EpiMag 96-Well Microplate (5/pack) |
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| Q10003 | EpiGentek |
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Human Genomic DNA |
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| X11000 | EpiGentek |
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Human Brain Genomic DNA |
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| X11001 | EpiGentek |
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DNA Methylation Antibody Panel Pack I |
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| C20000 | EpiGentek |
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XStamp Pro anti-PD-1 EV Targeting Kit |
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| XSTP915A-1 | SBI | 10 rxn | EUR 966 |
ACE2, His-Tag Protein |
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| E80019 | EpiGentek |
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SARS-CoV-2 Spike S1 (13-665) Protein, Fc Fusion, Avi-tag |
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| E80020 | EpiGentek |
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SARS-CoV-2 Spike S1 (16-685) Protein, Avi-His-tag |
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| E80021 | EpiGentek |
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SARS-CoV-2 Spike S1 (16-685) Protein, Fc Fusion, Avi-tag |
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| E80022 | EpiGentek |
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SARS-CoV-2 Spike S1 RBD (V367F) Protein, Avi-His-tag |
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| E80023 | EpiGentek |
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SARS-CoV-2 Spike S1 RBD Protein, Avi-His-tag |
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| E80024 | EpiGentek |
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SARS-CoV-2 Spike S1 RBD Protein, Human Fc-Fusion, Avi-Tag |
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| E80025 | EpiGentek |
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SARS-CoV-2 Spike S1 RBD Protein, Mouse Fc-fusion |
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| E80026 | EpiGentek |
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SARS-CoV-2 Nucleocapsid Protein, Avi-His-tag |
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| E80027 | EpiGentek |
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Recombinant SARS-CoV-2 Spike Glycoprotein(S) (D614G), Partial |
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| E80028 | EpiGentek |
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Substance P (1-4) [H-Arg-Pro-Lys-Pro-OH; MW: 496.6] |
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| SP-55176-1 | Alpha Diagnostics | 5 mg | EUR 196.8 |
Online Filter Kit |
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| 18-1027-11 | Scientific Laboratory Supplies | EACH | EUR 128.82 |
HCV-1 e2 Protein (484 - 499) (AA: Pro-Tyr-Cys-Trp-His-Tyr-Pro-Pro-Lys-Pro-Cys-Gly-Ile-Val-Pro-Ala) (MW: 1828.19) |
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| SP-52590-1 | Alpha Diagnostics | 1 mg | EUR 196.8 |
Methylamp 96 DNA Modification Kit |
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| P-1008 | EpiGentek |
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Nucleic Acid Isolation Enhancer (Glycogen Solution) |
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| R-1001 | EpiGentek |
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Methylamp PCR Enhancer |
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| R-1002 | EpiGentek |
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Streptavidin: HRP Conjugate |
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| R-1098 | EpiGentek |
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Streptavidin |
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| R-1100 | EpiGentek |
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Protease Inhibitor Cocktail |
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| R-1101 | EpiGentek |
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Streptavidin-Coated Strip Microwell Plate (Flat) |
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| R-1102 | EpiGentek |
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DNA High Binding Solution |
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| R-1103 | EpiGentek |
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DTT Solution |
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| R-1104 | EpiGentek |
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EpiQuik Nuclear Extraction Kit |
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| OP-0002 | EpiGentek |
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C-Series Mouse Inflammation Array Analysis Software |
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| S02-AAM-INF-1 | Neuromics | CD | EUR 325.2 |
POD PROTECTION (1/PK) |
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| P0DC0VER1 | Scientific Laboratory Supplies | EACH | EUR 313.5 |
Substance P (1-7) [H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-OH; MW: 9.6] |
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| SP-55247-1 | Alpha Diagnostics | 1 mg | EUR 196.8 |
?-Gliadin (57?73) [Gln-Leu-Gln-Pro-Phe-Pro-Gln-Pro-Glu-Leu-Pro-Tyr-Pro-Gln-Pro-Gln-Ser (MW: 1994.25)] |
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| SP-58780-1 | Alpha Diagnostics | 1 mg | EUR 196.8 |
Pro-Adrenomedullin (153-185), human |
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| A1101-1 | ApexBio | 1 mg | EUR 268.8 |
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Description: Pro-Adrenomedullin(153-185),human, (C143H224N42O43), a peptide with the sequence H2N-SLPEAGPGRTLVSSKPQAHGAPAPPSGSAPHFL-OH, MW= 3219.6. Adrenomedullin (AM) is a ubiquitously expressed peptide initially isolated from phaechromyctoma in 1993(1). |
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Recombinant Transmembrane Protease Serine 2 Protein, Partial |
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| E80016 | EpiGentek |
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Recombinant TMPRSS2 Protein, Partial |
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| E80017 | EpiGentek |
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Recombinant Novel Coronavirus Spike Glycoprotein(S), Partial |
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| E80018 | EpiGentek |
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Cytiva Online Filter Kit |
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| 18-1120-94 | Scientific Laboratory Supplies | EACH | EUR 111.72 |
Chorionic Gonadotropin-?(109-145) (human) (AA: Thr-Cys-Asp-Asp-Pro-Arg-Phe-Gln-Asp-Ser-Ser-Ser-Ser-Lys-Ala-Pro-Pro-Pro-Ser-Leu-Pro-Ser-Pro-Ser-Arg-Leu-Pro-Gly-Pro-Ser-Asp-Thr-Pro-Ile-Leu-Pro-Gln) (MW: 1268.31) |
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| SP-62542-1 | Alpha Diagnostics | 1 mg | EUR 416.4 |
Substance P (1-9) [H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-OH; MW: 114.3] |
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| SP-55327-1 | Alpha Diagnostics | 1 mg | EUR 169.2 |
Neurotensin (1-11) [pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-OH; MW 1446.66] |
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| SP-55373-1 | Alpha Diagnostics | 1 mg | EUR 169.2 |
HBV core protein (128-140) [H-Thr-Pro-Pro-Ala-Tyr-Arg-Pro-Pro-Asn-Ala-Pro-Ile-Leu-OH; MW: 1406.64] |
|||
| SP-52142-1 | Alpha Diagnostics | 0.5 mg | EUR 169.2 |
Brain Derived Basic Fibroblast Growth Factor (1-24) (AA: Pro-Ala-Leu-Pro-Glu-Asp-Gly-Gly-Ser-Gly-Ala-Phe-Pro-Pro-Gly-His-Phe-Lys-Asp-Pro-Lys-Arg-Leu-Tyr) (MW: 2553.86) |
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| SP-101818-1 | Alpha Diagnostics | 1 mg | EUR 270 |
FDC - SP (61 - 85), human (AA: Phe-Pro-Trp-Phe-Arg-Arg-Asn-Phe-Pro-Ile-Pro-Ile-Pro-Glu-Ser-Ala-Pro-Thr-Thr-Pro-Leu-Pro-Ser-Glu-Lys) (MW: 2925.41) |
|||
| SP-100816-1 | Alpha Diagnostics | 1 mg | EUR 270 |
Salusin-? (AA: Ser-Gly-Ala-Leu-Pro-Pro-Ala-Pro-Ala-Ala-Pro-Arg-Pro-Ala-Leu-Arg-Ala-Gln-Arg-Ala-Gly-Pro-Ala-Gly-Pro-Gly-Ala-Lys-NH2) (MW: 2603.05) |
|||
| SP-54847-1 | Alpha Diagnostics | 1 mg | EUR 343.2 |
KL-1 [H-Leu-Pro-Pro-Val-Ala-Ala-Ser-Ser-Leu-Arg-Asn-Asp-OH; MW: 1239.4] |
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| SP-55382-1 | Alpha Diagnostics | 1 mg | EUR 343.2 |
Cripto-1, CR-1 (AA: Cys-Pro-Pro-Ser-Phe-Tyr-Gly-Arg-Asn-Cys-Glu-His-Asp-Val-Arg-Lys-Glu) (MW: 2037.26) |
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| SP-60896-1 | Alpha Diagnostics | 1 mg | EUR 196.8 |
Gastrin Releasing Peptide (1-16), human (AA: Val-Pro-Leu-Pro-Ala-Gly-Gly-Gly-Thr-Val-Leu-Thr-Lys-Met-Tyr-Pro) (MW: 1600.9) |
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| SP-101813-1 | Alpha Diagnostics | 1 mg | EUR 196.8 |
Anti-pro Caspase 9 Rabbit Monoclonal Antibody |
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| M00080-1 | BosterBio | 100ug/vial | EUR 476.4 |
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Description: Rabbit Monoclonal pro Caspase 9 Antibody. Validated in WB and tested in Human. |
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Anti-pro Caspase 3 Rabbit Monoclonal Antibody |
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| M00334-1 | BosterBio | 100ug/vial | EUR 476.4 |
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Description: Rabbit Monoclonal pro Caspase 3 Antibody. Validated in IP, IF, WB and tested in Human, Mouse. |
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XStamp Pro Streptavidin Customizable EV Targeting Kit |
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| XSTP900A-1 | SBI | 10 rxn | EUR 966 |
XStamp Pro anti-HIV EV Targeting Kit |
|||
| XSTP905A-1 | SBI | 10 rxn | EUR 966 |
XStamp Pro anti-CD16 EV Targeting Kit |
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| XSTP910A-1 | SBI | 10 rxn | EUR 966 |
RFRP-1 (Human) [H-Met-Pro-His-Ser-Phe-Ala-Asn-Leu-Pro-Leu-Arg-Phe-NH2; MW: 1428.73] |
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| SP-55402-1 | Alpha Diagnostics | 0.5 mg | EUR 169.2 |
Fibrinogen ?-Chain (24-42) (AA: Glu-Glu-Ala-Pro-Ser-Leu-Arg-Pro-Ala-Pro-Pro-Pro-Ile-Ser-Gly-Gly-Gly-Tyr-Arg) (MW: 1951.19) |
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| SP-88462-1 | Alpha Diagnostics | 1 mg | EUR 343.2 |
Osteocalcin (1-49) (human) [Tyr-Leu-Tyr-Gln-Trp-Leu-Gly-Ala-Pro-Val-Pro-Tyr-Pro-Asp-Pro-Leu-Gla-Pro-Arg-Arg-Gla-Val-Cys-Gla-Leu-Asn-Pro-Asp-Cys-Asp-Glu-Leu-Ala-Asp-His-Ile-Gly-Phe-Gln-Glu-Ala-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val] |
|||
| SP-75987-1 | Alpha Diagnostics | 0.1 mg | EUR 489.6 |
Big Endothelin-1 (22-39), rat (AA: Val-Asn-Thr-Pro-Glu-Arg-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Ser-Arg-Ser) (MW: 1915.2) |
|||
| SP-101770-1 | Alpha Diagnostics | 1 mg | EUR 196.8 |
Big Endothelin-1 Fragment (22-38) (human) (AA: Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser) (MW: 1809.03) |
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| SP-89901-1 | Alpha Diagnostics | 1 mg | EUR 196.8 |
Printer |
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| B4000-P | Benchmark Scientific | 1 PC | EUR 115.58 |
Somatostatin 28 (1-12) [H-Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-OH; MW: 1244.36] |
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| SP-55387-1 | Alpha Diagnostics | 1 mg | EUR 343.2 |
QHub Software |
|||
| MVSQHS100 | Neuromics | CD Disk | EUR 12579.6 |
Prepro-Atrial Natriuretic Factor (56-92) (human) (AA: Glu-Val-Val-Pro-Pro-Gln-Val-Leu-Ser-Glu-Pro-Asn-Glu-Glu-Ala-Gly-Ala-Ala-Leu-Ser-Pro-Leu-Pro-Glu-Val-Pro-Pro-Trp-Thr-Gly-Glu-Val-Ser-Pro-Ala-Gln-Arg) (MW: 3878.3) |
|||
| SP-100532-1 | Alpha Diagnostics | 1 mg | EUR 416.4 |
Prepro-adrenomedullin (153 - 185), human (AA: Ser-Leu-Pro-Glu-Ala-Gly-Pro-Gly-Arg-Thr-Leu-Val-Ser-Ser-Lys-Pro-Gln-Ala-His-Gly-Ala-Pro-Ala-Pro-Pro-Ser-Gly-Ser-Ala-Pro-His-Phe-Leu) (MW: 3219.6) |
|||
| SP-100826-1 | Alpha Diagnostics | 1 mg | EUR 270 |
Gastric Juice Peptide Fragmentc (AA: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) (MW: 1419.56) |
|||
| SP-76014-1 | Alpha Diagnostics | 1 mg | EUR 343.2 |
Fibrinolysis Inhibiting Factor [Gly-Pro-Arg-Pro-OH; MW: 425.49] |
|||
| SP-52247-1 | Alpha Diagnostics | 1 mg | EUR 196.8 |
[Phe22] Big Endothelin-1 (19-37), human [Ile-Ile-Trp-Phe-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg; MW 2182.53] |
|||
| SP-88401-1 | Alpha Diagnostics | 1 mg | EUR 196.8 |
Big Gastrin - 1, human (AA: Pyr-Leu-Gly-Pro-Gln-Gly-Pro-Pro-His-Leu-Val-Ala-Asp-Pro-Ser-Lys-Lys-Gln-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2) (MW: 3849.30) |
|||
| SP-88140-1 | Alpha Diagnostics | 1 mg | EUR 270 |
Neuregulin/Heregulin-1? (NRG-1?/HRG-1?), human recombinant protein |
|||
| P1054-1 | ApexBio | 1 mg | EUR 4736.4 |
|
Description: Neuregulin (NRG) is a signaling protein for ErbB2/ErbB4 receptor heterodimers on the cardiac muscle cells and plays an important role in heart structure and function through inducing cardiomyocyte differentiation |
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Endothelin-1 (1-15), amide, human |
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| A1111-1 | ApexBio | 1 mg | EUR 866.4 |
|
Description: Endothelins are 21-amino acid vasoconstricting peptides produced primarily in the endothelium and have a key role in vascular homeostasis. |
|||
Angiotensin 1/2 (1-7) amide |
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| A1054-1 | ApexBio | 1 mg | EUR 115.2 |
|
Description: Angiotensin I/II (1-7) amide (H2N-Asp-Arg-Val-Tyr-Ile-His-Pro-amide) is a peptide analog to angiotensin II that is used as a vasopressor in the treatment of certain types of shock and circulatory collapse. |
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Angiotensin 1/2 (1-8) amide |
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| A1055-1 | ApexBio | 1 mg | EUR 115.2 |
|
Description: The physiologically active peptide angiotensin-2 (angiotensin 1- 8) is yielded from angiotensin-1, a substrate of ACE (angiotensin converting enzyme), by removing a dipeptide. |
|||
Haptoglobin, (Phenotype 1-1) Human Plasma |
|||
| 7536-1 | Biovision | each | EUR 385.2 |
Zaire Ebola virus negative control peptide for SP-89925-1 (Tyr-Pro-Tyr-Asp-Val-Pro-Asp-Tyr-Ala) (MW: 1102.2) |
|||
| SP-89926-1 | Alpha Diagnostics | 1 mg | Ask for price |
Systemin [H-Ala-Val-Gln-Ser-Lys-Pro-Pro-Ser-Lys-Arg-Asp-Pro-Pro-Lys-Met-Gln-Thr-Asp-OH; MW: 21.32] |
|||
| SP-55162-1 | Alpha Diagnostics | 0.5 mg | EUR 169.2 |
UK 1 |
|||
| C5006-1 | ApexBio | 1 mg | EUR 435.6 |
|
Description: UK 1, an unusual bis-benzoxazole metabolite isolated from Streptomyces sp. 517-02, is an inhibitor of topoisomerase II (Topo II) and hepatitis C viral replication. |
|||
KP372-1 |
|||
| C5053-1 | ApexBio | 1 mg | EUR 158.4 |
|
Description: IC50: 30-60 nM for thyroid cancer cells KP372-1 is a specific Akt inhibitor. The phosphatidylinositol 3' kinase (PI3K)/phosphatase, which is a key regulator of cell proliferation and survival, is mutated or activated in various cancers. |
|||
CMPD-1 |
|||
| B2991-1 | Biovision | 1mg | EUR 150 |
TAPI-1 |
|||
| B4686-1 | ApexBio | 1 mg | EUR 321.6 |
|
Description: TAPI-1 is an inhibitor of tumour necrosis factor with IC50 value of 8.09 ?M [1].TAPI-1 is an inhibitor of TACE/ADAM17 which catalyzes the cleavage of full-length APP to the soluble N-terminal fragment (sAPP?). |
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C14TKL-1 |
|||
| B5240-1 | ApexBio | 1 mg | EUR 478.8 |
?1-MSH |
|||
| B5427-1 | ApexBio | 1 mg | EUR 321.6 |
MMK 1 |
|||
| B5446-1 | ApexBio | 1 mg | EUR 321.6 |
CRSP-1 |
|||
| B5452-.1 | ApexBio | 100 ug | EUR 498 |
ADWX 1 |
|||
| B5722-.1 | ApexBio | 100 ug | EUR 699.6 |
|
Description: ADWX 1 is a potent and selective inhibitor of KV1.3 channel with IC50 values of 1.89 pM and 0.65 nM for Kv1.3 and Kv1.1, respectively [1]. |
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Purotoxin 1 |
|||
| B5771-.1 | ApexBio | 100 µg | EUR 456 |
Shz 1 |
|||
| B5772-1 | ApexBio | 1 mg | EUR 141.6 |
Psalmotoxin 1 |
|||
| B5796-.1 | ApexBio | 100 ug | EUR 536.4 |
|
Description: IC50: 0.9 nMPsalmotoxin 1 is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker.Several ASIC subunits described: ASIC1a, ASIC1b, ASIC2a, ASIC2b, and ASIC3 with different kinetics, tissue distribution, and external pH sensitivities. |
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Flutax 1 |
|||
| B6986-1 | ApexBio | 1 mg | EUR 478.8 |
IDE 1 |
|||
| B7566-1 | ApexBio | 1 mg | EUR 141.6 |
Rbin-1 |
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| B7823-1 | ApexBio | 1 mg | EUR 184.8 |
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Description: Rbin-1 is an eukaryotic ribosome assembly inhibitor.All cellular proteins are synthesized by ribosomes, whose biogenesis is a complex multi-step process quickly completed in eukaryotes. |
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4EGI-1 |
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| B2901-1 | Biovision | each | EUR 170.4 |
IQ-1 |
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| 1663-1 | Biovision | each | EUR 244.8 |
Shz-1 |
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| 1915-1 | Biovision | each | EUR 164.4 |
1-Azakenpaullone |
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| 1944-1 | Biovision | each | EUR 346.8 |
StemRegenin 1 |
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| 1967-1 | Biovision | each | EUR 176.4 |
SANT-1 |
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| 1978-1 | Biovision | each | EUR 151.2 |
TAPI-1 |
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| 2068-1 | Biovision | each | EUR 477.6 |
IDE-1 |
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| 2193-1 | Biovision | each | EUR 176.4 |
PFI-1 |
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| 2203-1 | Biovision | each | EUR 138 |
Tenovin-1 |
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| 27660-1 | BPS Bioscience | 25 mg | EUR 155 |
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Description: Tenovin-1 inhibits the protein-deacetylating activities of SIRT1 and SIRT2. Tenovin-1 is also a p53 activator and elevates the amount of p53 protein within 2 hr of treatment, without altering p53 mRNA levels. Tenovin-1 protects against MDM2-mediated p53 degradation via ubiquitination. |
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ERKtide (AA: Ala-Thr-Gly-Pro-Leu-Ser-Pro-Gly-Pro-Phe-Gly-Arg-Arg) (MW: 1312.51) |
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| SP-86711-1 | Alpha Diagnostics | 1 mg | EUR 196.8 |
BNP (1-21), Pro (Human) (AA: His-Pro-Leu-Gly-Ser-Pro-Gly-Ser-Ala-Ser-Asp-Leu-Glu-Thr-Ser-Gly-Leu-Gln-Glu-Gln-Arg) (MW: 2166.31) |
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| SP-87476-1 | Alpha Diagnostics | 1 mg | EUR 196.8 |
TA-0910, taltirelin (AA: 1-methyl-4,5-dihydroorotyl-His-Pro-NH2) (MW: 405.41) |
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| SP-100286-1 | Alpha Diagnostics | 1 mg | EUR 270 |
ProMMP-9 Pro-Matrix Metalloproteinase-9 Human Recombinant Protein |
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| PROTP14780-1 | BosterBio | Regular: 10ug | EUR 380.4 |
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Description: Pro-MMP-9 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 688 amino acids fragment (20-707) corresponding to the pro form of the protein minus the signal peptide, having a total molecular mass of 78.59kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. ;The Pro-MMP-9 is purified by proprietary chromatographic techniques. |
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Enterostatin, Human [H-Ala-Pro-Gly-Pro-Arg-OH; MW: 572.69] |
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| SP-52242-1 | Alpha Diagnostics | 5 mg | EUR 196.8 |
Lastly, the dendritic impact of HspB5 was investigated beneath a pathophysiological situation, i.e. iron deficiency which reportedly leads to dendritic rarefaction. HspB5 and HspB5-AEE however not the non-phosphorylatable mutant HspB5-AAA considerably counteracted the dendritic rarefaction. Thus, our information counsel that upregulation and selective phosphorylation of HspB5 in neurodegenerative ailments could protect dendritic morphology and counteract neuronal dysfunction.