Background: Decreased cardiac contractility has been noticed in cirrhosis, however the mechanisms that provoke and preserve cardiac dysfunction will not be fully understood.
Intention of the examine: We check the speculation that cirrhotic cardiomyopathy is expounded to deterioration of myocardial contractility on account of alterations in calcium-handling proteins expression. As well as, we evaluated whether or not cardiac pro-inflammatory cytokine ranges are related to this course of.
Strategies: Cirrhosis was induced by thioacetamide (TAA, 100 mg/kg/i.p., twice weekly for eight weeks). The myocardial efficiency was evaluated in remoted left ventricle papillary muscle mass beneath basal situations and after inotropic problem. The cardiac calcium dealing with protein expression was detected by Western blotting. Cardiac TNF-α and IL-6 ranges had been measured by ELISA.
Outcomes: Thioacetamide induced liver cirrhosis, which was related to cirrhotic cardiomyopathy characterised by in vivo left ventricular diastolic and systolic dysfunction in addition to cardiac hypertrophy. In vitro baseline myocardial contractility was decrease in cirrhosis. Additionally, myocardial responsiveness to post-rest contraction stimulus was declined. Protein expression for RYR2, SERCA2, NCX, pPBL Ser16 and L-type calcium channel was quantitatively unchanged; nonetheless, pPBL Thr17 was considerably decrease whereas IL-6 was larger.
Conclusions: Our examine demonstrates that cirrhotic cardiomyopathy is related to decreased cardiac contractility with alteration of phospholamban phosphorylation in affiliation with larger cardiac pro-inflammatory IL-6 ranges. These findings offered molecular and practical insights concerning the results of liver cirrhosis on cardiac operate.
Nucleolin regulates 14-3-3ζ mRNA and promotes cofilin phosphorylation to induce tunneling nanotube formation
Tunneling nanotubes (TNTs) mediate intercellular communication between animal cells in well being and illness, however the mechanisms of their biogenesis and performance are poorly understood. Right here we report that the RNA-binding protein (RBP) nucleolin, which interacts with the identified TNT-inducing protein MSec, is crucial for TNT formation in mammalian cells. Nucleolin, by way of its RNA-binding domains (RBDs), binds to and maintains the cytosolic ranges of 14-3-3ζ mRNA, and is, subsequently, required for TNT formation. A particular area of the three’-untranslated area (UTR) of the 14-3-3ζ mRNA is more likely to be concerned in its regulation by nucleolin. Purposeful complementation experiments counsel that nucleolin and 14-3-3ζ kind a linear signaling axis that promotes the phosphorylation and inactivation of the F-actin depolymerization issue cofilin to induce TNT formation.
MSec additionally equally inactivates cofilin, however potentiates TNT formation impartial of the nucleolin-14-3-3ζ axis, regardless of biochemically interacting with each proteins. We present that 14-3-3ζ and nucleolin are required for the formation of TNTs between major mouse neurons and astrocytes and in a number of different mammalian cell varieties. We additionally report that the Caenorhabditis elegans orthologs of 14-3-3ζ and MSec regulate the dimensions and structure of the TNT-like mobile protrusions of the distal tip cell (DTC), the germline stem cell area of interest within the gonad. Our examine demonstrates a novel and probably conserved mRNA-guided mechanism of TNT formation by way of the upkeep of mobile 14-3-3ζ mRNA ranges by the RBP nucleolin.
The retinoblastoma tumour suppressor protein (RB) performs an necessary function in organic processes reminiscent of cell cycle management, DNA harm restore, epigenetic regulation, and genome stability. The canonical mannequin of RB regulation is that cyclin-CDKs phosphorylate, and render RB inactive in late G1/S, selling entry into S section. Not too long ago, mono-phosphorylated RB species had been described to have distinct cell-cycle impartial capabilities, suggesting {that a} phosphorylation code dictates range of RB operate. Nevertheless, a biologically related, practical function of RB phosphorylation at non-CDK websites has remained elusive.
HspB5/αB-crystallin phosphorylation at S45 and S59 is crucial for defense of the dendritic tree of rat hippocampal neurons
Rarefaction of the dendritic tree resulting in neuronal dysfunction is a trademark of many neurodegenerative ailments and we’ve proven beforehand that warmth shock protein B5 (HspB5)/αB-crystallin is ready to enhance dendritic complexity in vitro. The purpose of this examine was to research if this impact can be current in vivo, if HspB5 can counteract dendritic rarefaction beneath pathophysiological situations and the impression of phosphorylation of HspB5 on this course of. HspB5 and eight mutants inhibiting or mimicking phosphorylation on the three phosphorylation websites serine (S)19, S45 and S59 had been overexpressed in cultured rat hippocampal neurons with subsequent investigation of the complexity of the dendritic tree.
Sholl evaluation revealed vital larger complexity of the dendritic tree after overexpression of wildtype HspB5 and the mutant HspB5-AEE. All different mutants confirmed no or minor results. For in vivo investigation in utero electroporation of mouse embryos was utilized. At embryonal day E15.5 the respective plasmids had been injected, cornu ammonis 1 (CA1) pyramidal cells transfected by electroporation and their basal dendritic tree analyzed at postnatal day P15. In vivo, HspB5 and HspB5-AEE led to a rise of whole dendritic size in addition to the next complexity.
CODESOFT Pro 3THT - Renew AE Software |
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196576 | BRADY NV | Box of 1 Piece(s) | EUR 168 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Pro 1THT - Renew AE Software |
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196580 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Pro 1THT - Renew AE Software |
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196587 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Pro 3THT - Renew AE Software |
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196588 | BRADY NV | Box of 1 Piece(s) | EUR 168 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Pro 1THT - ECE - Renew AE Software |
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196522 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Pro 1THT - ECE - Renew AE Software |
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196531 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Pro 3THT - ECE - Renew AE Software |
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196536 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Pro 1THT - ECE - Renew AE Software |
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196537 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Pro 3THT - ECE - Renew AE Software |
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196541 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Pro 1THT - ECE - Renew AE Software |
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196542 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Pro 3THT - ECE - Renew AE Software |
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196552 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Pro 3THT - ECE - Renew AE Software |
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196554 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Lite - Renew AE Software |
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196527 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Lite - Renew AE Software |
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196579 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Lite - Renew AE Software |
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196581 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Lite - Renew AE Software |
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196584 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT NW RFID 1 user - Renew AE Software |
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196534 | BRADY NV | Box of 1 Piece(s) | EUR 409.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT NW RFID 1 user - Renew AE Software |
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196543 | BRADY NV | Box of 1 Piece(s) | EUR 409.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT NW RFID 1 user - Renew AE Software |
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196565 | BRADY NV | Box of 1 Piece(s) | EUR 409.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT NW RFID 1 user - Renew AE Software |
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196585 | BRADY NV | Box of 1 Piece(s) | EUR 409.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CS Pro 1 THT-PLSW -1 year SMA new AE Software |
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196180 | BRADY NV | Box of 1 Piece(s) | EUR 871.5 |
Description: Description Dutch: Codesoft Pro 1 THT Printer - PL Software Key Protection - 1 year SMA new; Description French: Codesoft Pro 1 THT Printer - PL Software Key Protection - 1 year SMA new |
CS Pro 1 THT -ECE-1 year SMA-RENEW AE Software |
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196090 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
Description: Description Dutch: Codesoft Pro 1 THT Printer -ECE - 1 year SMA - Renewal SMA Renewal; Description French: Codesoft Pro 1 THT Printer -ECE - 1 year SMA - Renewal SMA Renewal |
CODESOFT Lite - ECE - Renew AE Software |
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196523 | BRADY NV | Box of 1 Piece(s) | EUR 63 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Lite - ECE - Renew AE Software |
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196533 | BRADY NV | Box of 1 Piece(s) | EUR 63 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Lite - ECE - Renew AE Software |
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196551 | BRADY NV | Box of 1 Piece(s) | EUR 63 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Lite - ECE - Renew AE Software |
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196567 | BRADY NV | Box of 1 Piece(s) | EUR 63 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT NW RFID 1 user - VM Renew AE Software |
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196597 | BRADY NV | Box of 1 Piece(s) | EUR 619.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT NW RFID 1 user - VM Renew AE Software |
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196598 | BRADY NV | Box of 1 Piece(s) | EUR 619.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT NW RFID 1 user - VM Renew AE Software |
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196599 | BRADY NV | Box of 1 Piece(s) | EUR 619.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CS Pro 3 THT-PLSW -1 year SMA new AE Software |
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196145 | BRADY NV | Box of 1 Piece(s) | EUR 1081.5 |
Description: Description Dutch: Codesoft Pro 3 THT Printer - PL Software Key Protection - 1 year SMA new; Description French: Codesoft Pro 3 THT Printer - PL Software Key Protection - 1 year SMA new |
CS Pro 1 THT-PLSW -3 year SMA new AE Software |
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196159 | BRADY NV | Box of 1 Piece(s) | EUR 1102.5 |
Description: Description Dutch: Codesoft Pro 1 THT Printer - PL Software Key Protection - 3 year SMA new; Description French: Codesoft Pro 1 THT Printer - PL Software Key Protection - 3 year SMA new |
CODESOFT Runtime RFID - Renew AE Software |
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196535 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Runtime RFID - Renew AE Software |
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196539 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Runtime RFID - Renew AE Software |
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196540 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Runtime RFID - Renew AE Software |
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196590 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CS Pro 3 THT-ECE-1 year SMA-RENEW AE Software |
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196161 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
Description: Description Dutch: Codesoft Pro 3 THT Printer - ECE - 1 year SMA - Renewal SMA Renewal; Description French: Codesoft Pro 3 THT Printer - ECE - 1 year SMA - Renewal SMA Renewal |
CODESOFT Enterprise RFID - Renew AE Software |
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196559 | BRADY NV | Box of 1 Piece(s) | EUR 252 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Enterprise RFID - Renew AE Software |
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196561 | BRADY NV | Box of 1 Piece(s) | EUR 252 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Enterprise RFID - Renew AE Software |
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196563 | BRADY NV | Box of 1 Piece(s) | EUR 252 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Enterprise RFID - Renew AE Software |
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196583 | BRADY NV | Box of 1 Piece(s) | EUR 252 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CS Pro 1 THT-ECE-PLSW -1 year SMA new AE Software |
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196095 | BRADY NV | Box of 1 Piece(s) | EUR 598.5 |
Description: Description Dutch: Codesoft Pro 1 THT Printer - ECE - PL Software Key Protection - 1 year SMA new; Description French: Codesoft Pro 1 THT Printer - ECE - PL Software Key Protection - 1 year SMA new |
CODESOFT Runtime RFID - VM Renew AE Software |
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196591 | BRADY NV | Box of 1 Piece(s) | EUR 157.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Runtime RFID - VM Renew AE Software |
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196592 | BRADY NV | Box of 1 Piece(s) | EUR 157.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Runtime RFID - VM Renew AE Software |
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196593 | BRADY NV | Box of 1 Piece(s) | EUR 157.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT NW RFID 5 users - Renew AE Software |
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196521 | BRADY NV | Box of 1 Piece(s) | EUR 661.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT NW RFID 5 users - Renew AE Software |
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196524 | BRADY NV | Box of 1 Piece(s) | EUR 661.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT NW RFID 5 users - Renew AE Software |
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196532 | BRADY NV | Box of 1 Piece(s) | EUR 661.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT NW RFID 5 users - Renew AE Software |
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196586 | BRADY NV | Box of 1 Piece(s) | EUR 661.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Enterprise RFID - VM Renew AE Software |
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196594 | BRADY NV | Box of 1 Piece(s) | EUR 388.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Enterprise RFID - VM Renew AE Software |
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196595 | BRADY NV | Box of 1 Piece(s) | EUR 388.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT Enterprise RFID - VM Renew AE Software |
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196596 | BRADY NV | Box of 1 Piece(s) | EUR 388.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CS Pro 1 THT-ECE-PLSW -3 year SMA new AE Software |
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196156 | BRADY NV | Box of 1 Piece(s) | EUR 787.5 |
Description: Description Dutch: Codesoft Pro 1 THT Printer - ECE - PL Software Key Protection - 3 year SMA new; Description French: Codesoft Pro 1 THT Printer - ECE - PL Software Key Protection - 3 year SMA new |
CS Pro 3 THT-ECE-PLSW -1 year SMA new AE Software |
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196164 | BRADY NV | Box of 1 Piece(s) | EUR 756 |
Description: Description Dutch: Codesoft Pro 3 THT Printer - ECE - PL Software Key Protection - 1 year SMA new; Description French: Codesoft Pro 3 THT Printer - ECE - PL Software Key Protection - 1 year SMA new |
CODESOFT RT NW RFID 5 users - Renew AE Software |
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196553 | BRADY NV | Box of 1 Piece(s) | EUR 304.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT RT NW RFID 5 users - Renew AE Software |
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196556 | BRADY NV | Box of 1 Piece(s) | EUR 304.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT RT NW RFID 5 users - Renew AE Software |
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196557 | BRADY NV | Box of 1 Piece(s) | EUR 304.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT RT NW RFID 5 users - Renew AE Software |
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196589 | BRADY NV | Box of 1 Piece(s) | EUR 304.5 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT NW RFID 5 users - VM Renew AE Software |
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196600 | BRADY NV | Box of 1 Piece(s) | EUR 1008 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT NW RFID 5 users - VM Renew AE Software |
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196601 | BRADY NV | Box of 1 Piece(s) | EUR 1008 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CODESOFT NW RFID 5 users - VM Renew AE Software |
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196602 | BRADY NV | Box of 1 Piece(s) | EUR 1008 |
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
CS Pro 3 THT-PLSW -3 year SMA new AE Software |
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196142 | BRADY NV | Box of 1 Piece(s) | EUR 1375.5 |
Description: Description Dutch: Codesoft Pro 3 THT Printer - PL Software Key Protection - 3 year SMA new; Description French: Codesoft Pro 3 THT Printer - PL Software Key Protection - 3 year SMA new |
CS Pro 3 THT-ECE-PLSW -3 year SMA new AE Software |
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196186 | BRADY NV | Box of 1 Piece(s) | EUR 997.5 |
Description: Description Dutch: Codesoft Pro 3 THT Printer - ECE - PL Software Key Protection - 3 year SMA new; Description French: Codesoft Pro 3 THT Printer - ECE - PL Software Key Protection - 3 year SMA new |
BMP71 Label Printer no Software - EACH |
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LAB4542 | Scientific Laboratory Supplies | EACH | EUR 1260.9 |
CS PRO 1 THT PRTR 1 SMA AE Software |
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363091 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
Description: Description Dutch: Codesoft Pro 1 THT Printer-1 year SMA; Description French: Codesoft Pro 1 THT Printer-1 year SMA |
CS Lite-PLSW -1 year SMA new AE Software |
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196173 | BRADY NV | Box of 1 Piece(s) | EUR 651 |
Description: Description Dutch: Codesoft Lite - PL Software Key Protection - 1 year SMA new; Description French: Codesoft Lite - PL Software Key Protection - 1 year SMA new |
CS PRO 3 THT PRTR 1 SMA AE Software |
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363092 | BRADY NV | Box of 1 Piece(s) | EUR 168 |
Description: Description Dutch: Codesoft Pro 3 THT Printer-1 year SMA; Description French: Codesoft Pro 3 THT Printer-1 year SMA |
CS PRO 1 THT PRTR USB 1 SMA AE Software |
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362882 | BRADY NV | Box of 1 Piece(s) | EUR 997.5 |
Description: Description Dutch: Codesoft Pro 1 THT Printer USB Protection 1 year SMA; Description French: Codesoft Pro 1 THT Printer USB Protection 1 year SMA |
CS PRO 1 THT PRTR SWON 1 SMA AE Software |
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362880 | BRADY NV | Box of 1 Piece(s) | EUR 871.5 |
Description: Description Dutch: Codesoft Pro 1 THT Printer Software Protection Online 1 year SMA; Description French: Codesoft Pro 1 THT Printer Software Protection Online 1 year SMA |
CS Lite-ECE-PLSW -1 year SMA new AE Software |
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196125 | BRADY NV | Box of 1 Piece(s) | EUR 325.5 |
Description: Description Dutch: Codesoft Lite - ECE - PL Software Key Protection - 1 year SMA new; Description French: Codesoft Lite - ECE - PL Software Key Protection - 1 year SMA new |
CS PRO 3 THT PRTR USB 1 SMA AE Software |
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362890 | BRADY NV | Box of 1 Piece(s) | EUR 1207.5 |
Description: Description Dutch: Codesoft Pro 3 THT Printer USB Protection 1 year SMA; Description French: Codesoft Pro 3 THT Printer USB Protection 1 year SMA |
CS PRO 1 THT PRTR USB 3 SMA AE Software |
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362944 | BRADY NV | Box of 1 Piece(s) | EUR 1228.5 |
Description: Description Dutch: Codesoft Pro 1 THT Printer USB Protection 3 year SMA; Description French: Codesoft Pro 1 THT Printer USB Protection 3 year SMA |
CS PRO 3 THT PRTR SWON 1 SMA AE Software |
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362888 | BRADY NV | Box of 1 Piece(s) | EUR 1081.5 |
Description: Description Dutch: Codesoft Pro 3 THT Printer Software Protection Online 1 year SMA; Description French: Codesoft Pro 3 THT Printer Software Protection Online 1 year SMA |
CS PRO 1 THT PRTR SWON 3 SMA AE Software |
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362942 | BRADY NV | Box of 1 Piece(s) | EUR 1102.5 |
Description: Description Dutch: Codesoft Pro 1 THT Printer Software Protection Online 3 year SMA; Description French: Codesoft Pro 1 THT Printer Software Protection Online 3 year SMA |
CS PRO 1 THT PRTR ECE USB 1 SMA AE Software |
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362886 | BRADY NV | Box of 1 Piece(s) | EUR 724.5 |
Description: Description Dutch: Codesoft Pro 1 THT Printer ECE USB Protection 1 year SMA; Description French: Codesoft Pro 1 THT Printer ECE USB Protection 1 year SMA |
CS PRO 1 THT PRTR ECE SWON 1 SMA AE Software |
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362884 | BRADY NV | Box of 1 Piece(s) | EUR 598.5 |
Description: Description Dutch: Codesoft Pro 1 THT Printer ECE Software Protection Online 1 year SMA; Description French: Codesoft Pro 1 THT Printer ECE Software Protection Online 1 year SMA |
CS Lite-PLSW -3 year SMA new AE Software |
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196153 | BRADY NV | Box of 1 Piece(s) | EUR 850.5 |
Description: Description Dutch: Codesoft Lite - PL Software Key Protection - 3 year SMA new; Description French: Codesoft Lite - PL Software Key Protection - 3 year SMA new |
ADD of 5 users for NW 5-1 year SMA AE Software |
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196124 | BRADY NV | Box of 1 Piece(s) | EUR 2173.5 |
Description: Description Dutch: Addition of 5 users for Network 5 users - 1 year SMA Add-on; Description French: Addition of 5 users for Network 5 users - 1 year SMA Add-on |
CS PRO 3 THT PRTR ECE USB 1 SMA AE Software |
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362894 | BRADY NV | Box of 1 Piece(s) | EUR 913.5 |
Description: Description Dutch: Codesoft Pro 3 THT Printer ECE USB Protection 1 year SMA; Description French: Codesoft Pro 3 THT Printer ECE USB Protection 1 year SMA |
CS PRO 1 THT PRTR ECE USB 3 SMA AE Software |
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362948 | BRADY NV | Box of 1 Piece(s) | EUR 913.5 |
Description: Description Dutch: Codesoft Pro 1 THT Printer ECE USB Protection 3 year SMA; Description French: Codesoft Pro 1 THT Printer ECE USB Protection 3 year SMA |
CS PRO 3 THT PRTR ECE SWON 1 SMA AE Software |
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362892 | BRADY NV | Box of 1 Piece(s) | EUR 756 |
Description: Description Dutch: Codesoft Pro 3 THT Printer ECE Software Protection Online 1 year SMA; Description French: Codesoft Pro 3 THT Printer ECE Software Protection Online 1 year SMA |
CS PRO 1 THT PRTR ECE SWON 3 SMA AE Software |
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362946 | BRADY NV | Box of 1 Piece(s) | EUR 787.5 |
Description: Description Dutch: Codesoft Pro 1 THT Printer ECE Software Protection Online 3 year SMA; Description French: Codesoft Pro 1 THT Printer ECE Software Protection Online 3 year SMA |
ADD of 5 users for RT NW 5-1 year SMA AE Software |
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196168 | BRADY NV | Box of 1 Piece(s) | EUR 1848 |
Description: Description Dutch: Addition of 5 users for Runtime Network 5 users - 1 year SMA Add-on; Description French: Addition of 5 users for Runtime Network 5 users - 1 year SMA Add-on |
CS Lite-ECE-PLSW -3 year SMA new AE Software |
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196116 | BRADY NV | Box of 1 Piece(s) | EUR 441 |
Description: Description Dutch: Codesoft Lite - ECE - PL Software Key Protection - 3 year SMA new; Description French: Codesoft Lite - ECE - PL Software Key Protection - 3 year SMA new |
CS PRO 3 THT PRTR USB 3 SMA AE Software |
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362952 | BRADY NV | Box of 1 Piece(s) | EUR 1501.5 |
Description: Description Dutch: Codesoft Pro 3 THT Printer USB Protection 3 year SMA; Description French: Codesoft Pro 3 THT Printer USB Protection 3 year SMA |
CS PRO 3 THT PRTR SWON 3 SMA AE Software |
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362950 | BRADY NV | Box of 1 Piece(s) | EUR 1375.5 |
Description: Description Dutch: Codesoft Pro 3 THT Printer Software Protection Online 3 year SMA; Description French: Codesoft Pro 3 THT Printer Software Protection Online 3 year SMA |
CS NW RFID 5Online SUBS New AE Software |
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196112 | BRADY NV | Box of 1 Piece(s) | EUR 2320.5 |
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
ADD of 5 users for NW 5-3 year SMA AE Software |
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196114 | BRADY NV | Box of 1 Piece(s) | EUR 2688 |
Description: Description Dutch: Addition of 5 users for Network 5 users - 3 year SMA Add-on; Description French: Addition of 5 users for Network 5 users - 3 year SMA Add-on |
CS PRO 3 THT PRTR ECE USB 3 SMA AE Software |
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362956 | BRADY NV | Box of 1 Piece(s) | EUR 1123.5 |
Description: Description Dutch: Codesoft Pro 3 THT Printer ECE USB Protection 3 year SMA; Description French: Codesoft Pro 3 THT Printer ECE USB Protection 3 year SMA |
CS PRO 3 THT PRTR ECE SWON 3 SMA AE Software |
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362954 | BRADY NV | Box of 1 Piece(s) | EUR 997.5 |
Description: Description Dutch: Codesoft Pro 3 THT Printer ECE Software Protection Online 3 year SMA; Description French: Codesoft Pro 3 THT Printer ECE Software Protection Online 3 year SMA |
CS RT NW RFID 5Online SUBS New AE Software |
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196144 | BRADY NV | Box of 1 Piece(s) | EUR 1060.5 |
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
ADD of 5 users for RT NW 5-3 year SMA AE Software |
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196105 | BRADY NV | Box of 1 Piece(s) | EUR 2289 |
Description: Description Dutch: Addition of 5 users for Runtime Network 5 users - 3 year SMA Add-on; Description French: Addition of 5 users for Runtime Network 5 users - 3 year SMA Add-on |
CS Pro 1THT-Online SUBS New AE Software |
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196183 | BRADY NV | Box of 1 Piece(s) | EUR 472.5 |
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
CS Pro 3THT-Online SUBS New AE Software |
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196110 | BRADY NV | Box of 1 Piece(s) | EUR 588 |
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
CS Pro 1THT-ECE-Online SUBS New AE Software |
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196129 | BRADY NV | Box of 1 Piece(s) | EUR 399 |
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
CS Pro 3THT-ECE-Online SUBS New AE Software |
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196136 | BRADY NV | Box of 1 Piece(s) | EUR 493.5 |
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
CS LT USB 1 SMA AE Software |
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362856 | BRADY NV | Box of 1 Piece(s) | EUR 777 |
Description: Description Dutch: Codesoft Lite USB Protection 1 year SMA; Description French: Codesoft Lite USB Protection 1 year SMA |
CS LT SWON 1 SMA AE Software |
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362854 | BRADY NV | Box of 1 Piece(s) | EUR 651 |
Description: Description Dutch: Codesoft Lite Software Protection Online 1 year SMA; Description French: Codesoft Lite Software Protection Online 1 year SMA |
CS RT RFID 1 SMA AE Software |
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363095 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
Description: Description Dutch: Codesoft Runtime RFID-1 year SMA; Description French: Codesoft Runtime RFID-1 year SMA |
CS ENT RFID 1 SMA AE Software |
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363081 | BRADY NV | Box of 1 Piece(s) | EUR 252 |
Description: Description Dutch: Codesoft Enterprise RFID-1 year SMA; Description French: Codesoft Enterprise RFID-1 year SMA |
SAF-TRAIN-ONLINE AE Software |
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197652 | BRADY NV | Piece of 1 Piece(s) | EUR 281.19 |
Description: Description Dutch: SafeTrak-opleiding eindgebruiker – 2 uur online; Description French: Formation des utilisateurs finaux de SafeTrak — 2 heures en ligne |
CS NW RFID 1 User 1 SMA AE Software |
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363086 | BRADY NV | Box of 1 Piece(s) | EUR 409.5 |
Description: Description Dutch: Codesoft Network RFID 1 User-1 year SMA; Description French: Codesoft Network RFID 1 User-1 year SMA |
CS LT ECE USB 1 SMA AE Software |
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362860 | BRADY NV | Box of 1 Piece(s) | EUR 451.5 |
Description: Description Dutch: Codesoft Lite ECE USB Protection 1 year SMA; Description French: Codesoft Lite ECE USB Protection 1 year SMA |
CS LT ECE SWON 1 SMA AE Software |
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362858 | BRADY NV | Box of 1 Piece(s) | EUR 325.5 |
Description: Description Dutch: Codesoft Lite ECE Software Protection Online 1 year SMA; Description French: Codesoft Lite ECE Software Protection Online 1 year SMA |
CS RT RFID USB 1 SMA AE Software |
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362903 | BRADY NV | Box of 1 Piece(s) | EUR 882 |
Description: Description Dutch: Codesoft Runtime RFID USB Protection 1 year SMA; Description French: Codesoft Runtime RFID USB Protection 1 year SMA |
CS ENT RFID USB 1 SMA AE Software |
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362846 | BRADY NV | Box of 1 Piece(s) | EUR 1974 |
Description: Description Dutch: Codesoft Enterprise RFID USB Protection 1 year SMA; Description French: Codesoft Enterprise RFID USB Protection 1 year SMA |
CS RT RFID SWON 1 SMA AE Software |
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362901 | BRADY NV | Box of 1 Piece(s) | EUR 756 |
Description: Description Dutch: Codesoft Runtime RFID Software Protection Online 1 year SMA; Description French: Codesoft Runtime RFID Software Protection Online 1 year SMA |
CS RT RFID PLSW 1 SMA AE Software |
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362905 | BRADY NV | Box of 1 Piece(s) | EUR 756 |
Description: Description Dutch: Codesoft Runtime RFID Platinum Software Key Protection 1 year SMA; Description French: Codesoft Runtime RFID Platinum Software Key Protection 1 year SMA |
CS ENT RFID SWON 1 SMA AE Software |
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362844 | BRADY NV | Box of 1 Piece(s) | EUR 1848 |
Description: Description Dutch: Codesoft Enterprise RFID Software Protection Online 1 year SMA; Description French: Codesoft Enterprise RFID Software Protection Online 1 year SMA |
CS ENT RFID PLSW 1 SMA AE Software |
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362848 | BRADY NV | Box of 1 Piece(s) | EUR 1848 |
Description: Description Dutch: Codesoft Enterprise RFID Platinum Software Key Protection 1 year SMA; Description French: Codesoft Enterprise RFID Platinum Software Key Protection 1 year SMA |
CS NW RFID 1 User USB 1 SMA AE Software |
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362864 | BRADY NV | Box of 1 Piece(s) | EUR 3055.5 |
Description: Description Dutch: Codesoft Network RFID 1 User USB Protection 1 year SMA; Description French: Codesoft Network RFID 1 User USB Protection 1 year SMA |
CS NW RFID 1 User SWON 1 SMA AE Software |
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362862 | BRADY NV | Box of 1 Piece(s) | EUR 2929.5 |
Description: Description Dutch: Codesoft Network RFID 1 User Software Protection Online 1 year SMA; Description French: Codesoft Network RFID 1 User Software Protection Online 1 year SMA |
CS NW RFID 1 User PLSW 1 SMA AE Software |
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362866 | BRADY NV | Box of 1 Piece(s) | EUR 2929.5 |
Description: Description Dutch: Codesoft Network RFID 1 User Platinum Software Key Protection 1 year SMA; Description French: Codesoft Network RFID 1 User Platinum Software Key Protection 1 year SMA |
CS RT NW 5 Users 1 SMA AE Software |
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363093 | BRADY NV | Box of 1 Piece(s) | EUR 304.5 |
Description: Description Dutch: Codesoft Runtime Network 5 users-1 year SMA; Description French: Codesoft Runtime Network 5 users-1 year SMA |
CS NW RFID 5 Users 1 SMA AE Software |
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363088 | BRADY NV | Box of 1 Piece(s) | EUR 661.5 |
Description: Description Dutch: Codesoft Network RFID 5 Users-1 year SMA; Description French: Codesoft Network RFID 5 Users-1 year SMA |
CS NW RFID 1 User USB 3 SMA AE Software |
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362926 | BRADY NV | Box of 1 Piece(s) | EUR 3759 |
Description: Description Dutch: Codesoft Network RFID 1 User USB Protection 3 year SMA; Description French: Codesoft Network RFID 1 User USB Protection 3 year SMA |
CS LT USB 3 SMA AE Software |
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362918 | BRADY NV | Box of 1 Piece(s) | EUR 976.5 |
Description: Description Dutch: Codesoft Lite USB Protection 3 year SMA; Description French: Codesoft Lite USB Protection 3 year SMA |
CS Lite-Online SUBS New AE Software |
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196181 | BRADY NV | Box of 1 Piece(s) | EUR 399 |
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
CS NW RFID 5 Users USB 1 SMA AE Software |
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362869 | BRADY NV | Box of 1 Piece(s) | EUR 4903.5 |
Description: Description Dutch: Codesoft Network RFID 5 User USB Protection 1 year SMA; Description French: Codesoft Network RFID 5 User USB Protection 1 year SMA |
CS NW RFID 1 User SWON 3 SMA AE Software |
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362924 | BRADY NV | Box of 1 Piece(s) | EUR 3633 |
Description: Description Dutch: Codesoft Network RFID 1 User Software Protection Online 3 year SMA; Description French: Codesoft Network RFID 1 User Software Protection Online 3 year SMA |
CS NW RFID 1 User PLSW 3 SMA AE Software |
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362928 | BRADY NV | Box of 1 Piece(s) | EUR 3633 |
Description: Description Dutch: Codesoft Network RFID 1 User Platinum Software Key Protection 3 year SMA; Description French: Codesoft Network RFID 1 User Platinum Software Key Protection 3 year SMA |
CS LT SWON 3 SMA AE Software |
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362916 | BRADY NV | Box of 1 Piece(s) | EUR 850.5 |
Description: Description Dutch: Codesoft Lite Software Protection Online 3 year SMA; Description French: Codesoft Lite Software Protection Online 3 year SMA |
CS NW RFID 1 user-Online SUBS New AE Software |
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196167 | BRADY NV | Box of 1 Piece(s) | EUR 1449 |
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
CS NW RFID 5 Users SWON 1 SMA AE Software |
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362867 | BRADY NV | Box of 1 Piece(s) | EUR 4777.5 |
Description: Description Dutch: Codesoft Network RFID 5 User Software Protection Online 1 year SMA; Description French: Codesoft Network RFID 5 User Software Protection Online 1 year SMA |
CS NW RFID 5 Users PLSW 1 SMA AE Software |
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362871 | BRADY NV | Box of 1 Piece(s) | EUR 4777.5 |
Description: Description Dutch: Codesoft Network RFID 5 User Platinum Software Key Protection 1 year SMA; Description French: Codesoft Network RFID 5 User Platinum Software Key Protection 1 year SMA |
CS RT NW RFID 5 Users USB 1 SMA AE Software |
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362898 | BRADY NV | Box of 1 Piece(s) | EUR 2299.5 |
Description: Description Dutch: Codesoft Runtime Network RFID 5 User USB Protection 1 year SMA; Description French: Codesoft Runtime Network RFID 5 User USB Protection 1 year SMA |
CS NW RFID VM 1 USER SWON 3 SMA AE Software |
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363218 | BRADY NV | Box of 1 Piece(s) | EUR 4788 |
Description: Description Dutch: CODESOFT Network RFID 1 user - VMSoftware Protection Online3 year SMA; Description French: CODESOFT Network RFID 1 user - VMSoftware Protection Online3 year SMA |
CS NW RFID VM 1 USER PLAT 3 SMA AE Software |
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363219 | BRADY NV | Box of 1 Piece(s) | EUR 4788 |
Description: Description Dutch: CODESOFT Network RFID 1 user - VMPlatinum Software Key Protection3 year SMA; Description French: CODESOFT Network RFID 1 user - VMPlatinum Software Key Protection3 year SMA |
CS RT NW RFID 5 Users SWON 1 SMA AE Software |
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362896 | BRADY NV | Box of 1 Piece(s) | EUR 2173.5 |
Description: Description Dutch: Codesoft Runtime Network RFID 5 User Software Protection Online 1 year SMA; Description French: Codesoft Runtime Network RFID 5 User Software Protection Online 1 year SMA |
CS RT NW RFID 5 Users PLSW 1 SMA AE Software |
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362900 | BRADY NV | Box of 1 Piece(s) | EUR 2173.5 |
Description: Description Dutch: Codesoft Runtime Network RFID 5 User Platinum Software Key Protection 1 year SMA; Description French: Codesoft Runtime Network RFID 5 User Platinum Software Key Protection 1 year SMA |
CS LT ECE USB 3 SMA AE Software |
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362922 | BRADY NV | Box of 1 Piece(s) | EUR 567 |
Description: Description Dutch: Codesoft Lite ECE USB Protection 3 year SMA; Description French: Codesoft Lite ECE USB Protection 3 year SMA |
CS RT RFID-Online SUBS New AE Software |
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196127 | BRADY NV | Box of 1 Piece(s) | EUR 399 |
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
CS LT ECE SWON 3 SMA AE Software |
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362920 | BRADY NV | Box of 1 Piece(s) | EUR 441 |
Description: Description Dutch: Codesoft Lite ECE Software Protection Online 3 year SMA; Description French: Codesoft Lite ECE Software Protection Online 3 year SMA |
CS RT RFID USB 3 SMA AE Software |
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362965 | BRADY NV | Box of 1 Piece(s) | EUR 1081.5 |
Description: Description Dutch: Codesoft Runtime RFID USB Protection 3 year SMA; Description French: Codesoft Runtime RFID USB Protection 3 year SMA |
CS ENT RFID-Online SUBS New AE Software |
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196152 | BRADY NV | Box of 1 Piece(s) | EUR 871.5 |
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
CS ENT RFID USB 3 SMA AE Software |
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362908 | BRADY NV | Box of 1 Piece(s) | EUR 2394 |
Description: Description Dutch: Codesoft Enterprise RFID USB Protection 3 year SMA; Description French: Codesoft Enterprise RFID USB Protection 3 year SMA |
CS RT RFID SWON 3 SMA AE Software |
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362963 | BRADY NV | Box of 1 Piece(s) | EUR 955.5 |
Description: Description Dutch: Codesoft Runtime RFID Software Protection Online 3 year SMA; Description French: Codesoft Runtime RFID Software Protection Online 3 year SMA |
CS RT RFID PLSW 3 SMA AE Software |
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362967 | BRADY NV | Box of 1 Piece(s) | EUR 955.5 |
Description: Description Dutch: Codesoft Runtime RFID Platinum Software Key Protection 3 year SMA; Description French: Codesoft Runtime RFID Platinum Software Key Protection 3 year SMA |
CS ENT RFID SWON 3 SMA AE Software |
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362906 | BRADY NV | Box of 1 Piece(s) | EUR 2268 |
Description: Description Dutch: Codesoft Enterprise RFID Software Protection Online 3 year SMA; Description French: Codesoft Enterprise RFID Software Protection Online 3 year SMA |
CS ENT RFID PLSW 3 SMA AE Software |
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362910 | BRADY NV | Box of 1 Piece(s) | EUR 2268 |
Description: Description Dutch: Codesoft Enterprise RFID Platinum Software Key Protection 3 year SMA; Description French: Codesoft Enterprise RFID Platinum Software Key Protection 3 year SMA |
CS Lite-ECE-Online SUBS New AE Software |
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196170 | BRADY NV | Box of 1 Piece(s) | EUR 231 |
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
CS Pro 1THT-PL SUBS New AE Software |
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196169 | BRADY NV | Box of 1 Piece(s) | EUR 472.5 |
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
CS Pro 3THT-PL SUBS New AE Software |
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196176 | BRADY NV | Box of 1 Piece(s) | EUR 588 |
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
CS Pro 1THT-USB SUBS New AE Software |
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196146 | BRADY NV | Box of 1 Piece(s) | EUR 472.5 |
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
Lastly, the dendritic impact of HspB5 was investigated beneath a pathophysiological situation, i.e. iron deficiency which reportedly leads to dendritic rarefaction. HspB5 and HspB5-AEE however not the non-phosphorylatable mutant HspB5-AAA considerably counteracted the dendritic rarefaction. Thus, our information counsel that upregulation and selective phosphorylation of HspB5 in neurodegenerative ailments could protect dendritic morphology and counteract neuronal dysfunction.