PI3K and PTEN are the second and third most extremely mutated proteins in most cancers following solely p53. Their actions oppose one another. PI3K phosphorylates signaling lipid PIP2 to PIP3. PTEN dephosphorylates it again. Driver mutations in each proteins accrue PIP3. PIP3 recruits Akt and PDK1 to the membrane, selling cell cycle development. Right here we assessment phosphorylation occasions and mutations in autoinhibition in PI3K and PTEN from the structural standpoint. Our goal is to make clear how they management the autoinhibited states. In autoinhibition a section or a subunit of the protein occludes its purposeful website. Protein-protein interfaces are sometimes solely marginally steady, making them delicate to adjustments in situations in dwelling cells. Phosphorylation can stabilize or destabilize the interfaces. Driver mutations generally destabilize them.
In analogy to ‘passenger mutations’, we coin ‘passenger phosphorylation’ to emphasise that the presence of a phosphorylation recognition sequence brand doesn’t essentially indicate perform. Relatively, it could merely mirror a statistical incidence. In each PI3K and PTEN autoinhibiting phosphorylation occasions are noticed within the occluding ‘piece’. In PI3Kα the ‘piece’ is the p85α subunit. In PTEN it’s the C-terminal section. In each enzymes the stabilized interface covers the area that attaches to the membrane. Driver mutations that set off rotation of the occluding piece or its deletion immediate activation. Up to now, each enzymes lack particular, potent medication.
We focus on the implications of detailed structural and mechanistic perception into oncogenic activation and the way it can advance allosteric precision oncology. Many types of cardiac illness, together with coronary heart failure, current with insufficient protein high quality management (PQC). Pathological situations usually contain impaired removing of terminally misfolded proteins. This ends in the formation of huge protein aggregates, which additional scale back mobile viability and cardiac perform. Cardiomyocytes have an intricately collaborative PQC system to reduce mobile proteotoxicity.
Smad3 C-terminal phosphorylation website mutation attenuates the hepatoprotective impact of salvianolic acid B towards hepatocarcinogenesis
Smad3 phosphorylation is implicated in hepatic fibro-carcinogenesis. Furthermore, Smad3 phospho-isoform pSmad3L and pSmad3C are reversible and antagonistic, and the steadiness may shift from carcinogenesis to tumor-suppression. pSmad3C has lately assigned to carry out a preventative impact towards major liver damage. Salvianolic acid B (Sal B), a element derived from Salvia miltiorrhiza, is empirically used for hepatic illnesses. Our prior examine clarified that Sal B may delay hepatic fibrosis-carcinoma development by changing pSmad3L/3C in mice.
Nonetheless, the roles of Smad3 phospho-isoform conversion and antagonism within the anti-hepatocarcinogenic results of Sal B in pSmad3C- or/and pSmad3L-mutated mice/cells stay obscure. Presently, corresponding doses/concentrations of Sal B was co-administrated to pSmad3C+/- mutational mice/plasmids-transfected HepG2 cells. Notably, in vivo purposeful research revealed that pSmad3C mutation attenuates Sal B-induced ameliorative results on histopathological traits and decreased serological biomarkers, and potential mechanism entails attenuation of will increase in pSmad3C/p21 and reduces in pSmad3L/PAI-1/c-Myc expression.
Expectedly, in vitro outcomes confirmed that up-regulating pSmad3C enhances the inhibitory results on proliferation, migration and contributes to apoptosis accompanied by a shift of pSmad3L/PAI-1/c-Myc oncogenic to pSmad3C/p21 tumour-suppressive signalling; nonetheless, reverse results happen when upregulated pSmad3L. This examine is the primary to determine pSmad3C as a key goal by which Sal B prevents hepatocarcinogenesis.
Additional Investigation into the Biochemical Results of Phosphorylation of Tropomyosin Tpm1.1(α). Serine-283 Is in Communication with the Midregion
The phosphorylated and unphosphorylated types of tropomyosin Tpm1.1(α) are ready from grownup rabbit coronary heart and in contrast biochemically. Electrophoresis confirms the excessive degree of enrichment of the chromatography fractions and is according to a single website of phosphorylation. Covalently certain phosphate teams at place 283 of Tpm1.1(α) enhance the speed of digestion at Leu-169, suggestive of a conformational rearrangement that extends to the midregion. Such a rearrangement, which is supported by ellipticity measurements between 25 and 42 °C, is according to a phosphorylation-mediated tightening of the interplay between varied myofilament parts. In a nonradioactive, co-sedimentation assay, phosphorylated Tpm1.1(α) shows a better affinity for F-actin in comparison with that of the unphosphorylated management .
Phosphorylation decreases the focus of skinny filaments required to achieve a half-maximal charge of launch of product from a pre-power stroke complicated [myosin-S1-2-deoxy-3-O-(N-methylanthraniloyl)ADP-Pi], as investigated by double-mixing stopped-flow fluorescence, suggestive of a change within the proportion of lively (turned on) and inactive (turned off) conformers, however comparable most charges of product launch are noticed with both sort of reconstituted skinny filament. Phosphorylated skinny filaments (pCa four and eight) show a better affinity for myosin-S1(ADP) versus the management state of affairs with out affecting isotherm steepness.
CODESOFT Enterprise RFID - Renew AE Software |
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| 196563 | BRADY NV | Box of 1 Piece(s) | EUR 252 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Enterprise RFID - Renew AE Software |
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| 196583 | BRADY NV | Box of 1 Piece(s) | EUR 252 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Enterprise RFID - VM Renew AE Software |
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| 196594 | BRADY NV | Box of 1 Piece(s) | EUR 388.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Enterprise RFID - VM Renew AE Software |
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| 196595 | BRADY NV | Box of 1 Piece(s) | EUR 388.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Enterprise RFID - VM Renew AE Software |
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| 196596 | BRADY NV | Box of 1 Piece(s) | EUR 388.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Runtime RFID - Renew AE Software |
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| 196535 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Runtime RFID - Renew AE Software |
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| 196539 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Runtime RFID - Renew AE Software |
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| 196540 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Runtime RFID - Renew AE Software |
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| 196590 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Runtime RFID - VM Renew AE Software |
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| 196591 | BRADY NV | Box of 1 Piece(s) | EUR 157.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Runtime RFID - VM Renew AE Software |
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| 196592 | BRADY NV | Box of 1 Piece(s) | EUR 157.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Runtime RFID - VM Renew AE Software |
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| 196593 | BRADY NV | Box of 1 Piece(s) | EUR 157.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT NW RFID 1 user - Renew AE Software |
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| 196534 | BRADY NV | Box of 1 Piece(s) | EUR 409.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT NW RFID 1 user - Renew AE Software |
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| 196543 | BRADY NV | Box of 1 Piece(s) | EUR 409.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT NW RFID 1 user - Renew AE Software |
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| 196565 | BRADY NV | Box of 1 Piece(s) | EUR 409.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT NW RFID 1 user - Renew AE Software |
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| 196585 | BRADY NV | Box of 1 Piece(s) | EUR 409.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT NW RFID 5 users - Renew AE Software |
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| 196521 | BRADY NV | Box of 1 Piece(s) | EUR 661.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT NW RFID 5 users - Renew AE Software |
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| 196524 | BRADY NV | Box of 1 Piece(s) | EUR 661.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT NW RFID 5 users - Renew AE Software |
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| 196532 | BRADY NV | Box of 1 Piece(s) | EUR 661.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT NW RFID 5 users - Renew AE Software |
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| 196586 | BRADY NV | Box of 1 Piece(s) | EUR 661.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT NW RFID 1 user - VM Renew AE Software |
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| 196597 | BRADY NV | Box of 1 Piece(s) | EUR 619.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT NW RFID 1 user - VM Renew AE Software |
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| 196598 | BRADY NV | Box of 1 Piece(s) | EUR 619.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT NW RFID 1 user - VM Renew AE Software |
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| 196599 | BRADY NV | Box of 1 Piece(s) | EUR 619.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT RT NW RFID 5 users - Renew AE Software |
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| 196553 | BRADY NV | Box of 1 Piece(s) | EUR 304.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT RT NW RFID 5 users - Renew AE Software |
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| 196556 | BRADY NV | Box of 1 Piece(s) | EUR 304.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT RT NW RFID 5 users - Renew AE Software |
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| 196557 | BRADY NV | Box of 1 Piece(s) | EUR 304.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT RT NW RFID 5 users - Renew AE Software |
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| 196589 | BRADY NV | Box of 1 Piece(s) | EUR 304.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT NW RFID 5 users - VM Renew AE Software |
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| 196600 | BRADY NV | Box of 1 Piece(s) | EUR 1008 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT NW RFID 5 users - VM Renew AE Software |
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| 196601 | BRADY NV | Box of 1 Piece(s) | EUR 1008 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
|||
CODESOFT NW RFID 5 users - VM Renew AE Software |
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| 196602 | BRADY NV | Box of 1 Piece(s) | EUR 1008 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Lite - Renew AE Software |
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| 196527 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Lite - Renew AE Software |
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| 196579 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
|||
CODESOFT Lite - Renew AE Software |
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| 196581 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
|
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
|||
CODESOFT Lite - Renew AE Software |
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| 196584 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Pro 3THT - Renew AE Software |
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| 196525 | BRADY NV | Box of 1 Piece(s) | EUR 168 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Pro 3THT - Renew AE Software |
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| 196530 | BRADY NV | Box of 1 Piece(s) | EUR 168 |
|
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Pro 1THT - Renew AE Software |
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| 196558 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
|||
CODESOFT Pro 1THT - Renew AE Software |
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| 196566 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
|
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
|||
CODESOFT Pro 3THT - Renew AE Software |
|||
| 196576 | BRADY NV | Box of 1 Piece(s) | EUR 168 |
|
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
|||
CODESOFT Pro 1THT - Renew AE Software |
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| 196580 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
|
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
|||
CODESOFT Pro 1THT - Renew AE Software |
|||
| 196587 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
|
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
|||
CODESOFT Pro 3THT - Renew AE Software |
|||
| 196588 | BRADY NV | Box of 1 Piece(s) | EUR 168 |
|
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
|||
CODESOFT Lite - ECE - Renew AE Software |
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| 196523 | BRADY NV | Box of 1 Piece(s) | EUR 63 |
|
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
|||
CODESOFT Lite - ECE - Renew AE Software |
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| 196533 | BRADY NV | Box of 1 Piece(s) | EUR 63 |
|
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
|||
CODESOFT Lite - ECE - Renew AE Software |
|||
| 196551 | BRADY NV | Box of 1 Piece(s) | EUR 63 |
|
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
|||
CODESOFT Lite - ECE - Renew AE Software |
|||
| 196567 | BRADY NV | Box of 1 Piece(s) | EUR 63 |
|
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
|||
CODESOFT Pro 1THT - ECE - Renew AE Software |
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| 196522 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
|
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
|||
CODESOFT Pro 1THT - ECE - Renew AE Software |
|||
| 196531 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
|
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
|||
CODESOFT Pro 3THT - ECE - Renew AE Software |
|||
| 196536 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
|
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
|||
CODESOFT Pro 1THT - ECE - Renew AE Software |
|||
| 196537 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
|
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
|||
CODESOFT Pro 3THT - ECE - Renew AE Software |
|||
| 196541 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
|
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
|||
CODESOFT Pro 1THT - ECE - Renew AE Software |
|||
| 196542 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
|
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
|||
CODESOFT Pro 3THT - ECE - Renew AE Software |
|||
| 196552 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
|
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
|||
CODESOFT Pro 3THT - ECE - Renew AE Software |
|||
| 196554 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
|
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
|||
CS NW RFID 5Online SUBS New AE Software |
|||
| 196112 | BRADY NV | Box of 1 Piece(s) | EUR 2320.5 |
|
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
|||
CS RT NW RFID 5Online SUBS New AE Software |
|||
| 196144 | BRADY NV | Box of 1 Piece(s) | EUR 1060.5 |
|
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
|||
CS ENT RFID USB 3 SMA AE Software |
|||
| 362908 | BRADY NV | Box of 1 Piece(s) | EUR 2394 |
|
Description: Description Dutch: Codesoft Enterprise RFID USB Protection 3 year SMA; Description French: Codesoft Enterprise RFID USB Protection 3 year SMA |
|||
CS ENT RFID SWON 3 SMA AE Software |
|||
| 362906 | BRADY NV | Box of 1 Piece(s) | EUR 2268 |
|
Description: Description Dutch: Codesoft Enterprise RFID Software Protection Online 3 year SMA; Description French: Codesoft Enterprise RFID Software Protection Online 3 year SMA |
|||
CS ENT RFID PLSW 3 SMA AE Software |
|||
| 362910 | BRADY NV | Box of 1 Piece(s) | EUR 2268 |
|
Description: Description Dutch: Codesoft Enterprise RFID Platinum Software Key Protection 3 year SMA; Description French: Codesoft Enterprise RFID Platinum Software Key Protection 3 year SMA |
|||
CS ENT RFID 1 SMA AE Software |
|||
| 363081 | BRADY NV | Box of 1 Piece(s) | EUR 252 |
|
Description: Description Dutch: Codesoft Enterprise RFID-1 year SMA; Description French: Codesoft Enterprise RFID-1 year SMA |
|||
CS ENT RFID VM SWON 3 SMA AE Software |
|||
| 363216 | BRADY NV | Box of 1 Piece(s) | EUR 3013.5 |
|
Description: Description Dutch: CODESOPT Enterprise RFID - VMSoftware Protection Online3 year SMA; Description French: CODESOPT Enterprise RFID - VMSoftware Protection Online3 year SMA |
|||
CS ENT RFID VM PLAT 3 SMA AE Software |
|||
| 363217 | BRADY NV | Box of 1 Piece(s) | EUR 3013.5 |
|
Description: Description Dutch: CODESOPT Enterprise RFID - VMPlatinum Software Key Protection3 year SMA; Description French: CODESOPT Enterprise RFID - VMPlatinum Software Key Protection3 year SMA |
|||
CS ENT RFID USB 1 SMA AE Software |
|||
| 362846 | BRADY NV | Box of 1 Piece(s) | EUR 1974 |
|
Description: Description Dutch: Codesoft Enterprise RFID USB Protection 1 year SMA; Description French: Codesoft Enterprise RFID USB Protection 1 year SMA |
|||
CS RT RFID USB 3 SMA AE Software |
|||
| 362965 | BRADY NV | Box of 1 Piece(s) | EUR 1081.5 |
|
Description: Description Dutch: Codesoft Runtime RFID USB Protection 3 year SMA; Description French: Codesoft Runtime RFID USB Protection 3 year SMA |
|||
CS ENT RFID SWON 1 SMA AE Software |
|||
| 362844 | BRADY NV | Box of 1 Piece(s) | EUR 1848 |
|
Description: Description Dutch: Codesoft Enterprise RFID Software Protection Online 1 year SMA; Description French: Codesoft Enterprise RFID Software Protection Online 1 year SMA |
|||
CS ENT RFID PLSW 1 SMA AE Software |
|||
| 362848 | BRADY NV | Box of 1 Piece(s) | EUR 1848 |
|
Description: Description Dutch: Codesoft Enterprise RFID Platinum Software Key Protection 1 year SMA; Description French: Codesoft Enterprise RFID Platinum Software Key Protection 1 year SMA |
|||
CS RT RFID SWON 3 SMA AE Software |
|||
| 362963 | BRADY NV | Box of 1 Piece(s) | EUR 955.5 |
|
Description: Description Dutch: Codesoft Runtime RFID Software Protection Online 3 year SMA; Description French: Codesoft Runtime RFID Software Protection Online 3 year SMA |
|||
CS RT RFID PLSW 3 SMA AE Software |
|||
| 362967 | BRADY NV | Box of 1 Piece(s) | EUR 955.5 |
|
Description: Description Dutch: Codesoft Runtime RFID Platinum Software Key Protection 3 year SMA; Description French: Codesoft Runtime RFID Platinum Software Key Protection 3 year SMA |
|||
CS ENT RFID-Online SUBS New AE Software |
|||
| 196152 | BRADY NV | Box of 1 Piece(s) | EUR 871.5 |
|
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
|||
CS RT RFID 1 SMA AE Software |
|||
| 363095 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
|
Description: Description Dutch: Codesoft Runtime RFID-1 year SMA; Description French: Codesoft Runtime RFID-1 year SMA |
|||
CS RT RFID VM SWON 3 SMA AE Software |
|||
| 363214 | BRADY NV | Box of 1 Piece(s) | EUR 1239 |
|
Description: Description Dutch: CODESOFT Runtime RFID - VMSoftware Protection Online3 year SMA; Description French: CODESOFT Runtime RFID - VMSoftware Protection Online3 year SMA |
|||
CS RT RFID VM PLAT 3 SMA AE Software |
|||
| 363215 | BRADY NV | Box of 1 Piece(s) | EUR 1239 |
|
Description: Description Dutch: CODESOFT Runtime RFID - VMPlatinum Software Key Protection3 year SMA; Description French: CODESOFT Runtime RFID - VMPlatinum Software Key Protection3 year SMA |
|||
CS RT RFID USB 1 SMA AE Software |
|||
| 362903 | BRADY NV | Box of 1 Piece(s) | EUR 882 |
|
Description: Description Dutch: Codesoft Runtime RFID USB Protection 1 year SMA; Description French: Codesoft Runtime RFID USB Protection 1 year SMA |
|||
CS RT RFID SWON 1 SMA AE Software |
|||
| 362901 | BRADY NV | Box of 1 Piece(s) | EUR 756 |
|
Description: Description Dutch: Codesoft Runtime RFID Software Protection Online 1 year SMA; Description French: Codesoft Runtime RFID Software Protection Online 1 year SMA |
|||
CS RT RFID PLSW 1 SMA AE Software |
|||
| 362905 | BRADY NV | Box of 1 Piece(s) | EUR 756 |
|
Description: Description Dutch: Codesoft Runtime RFID Platinum Software Key Protection 1 year SMA; Description French: Codesoft Runtime RFID Platinum Software Key Protection 1 year SMA |
|||
CS RT RFID-Online SUBS New AE Software |
|||
| 196127 | BRADY NV | Box of 1 Piece(s) | EUR 399 |
|
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
|||
CS Lite-PLSW -3 year SMA new AE Software |
|||
| 196153 | BRADY NV | Box of 1 Piece(s) | EUR 850.5 |
|
Description: Description Dutch: Codesoft Lite - PL Software Key Protection - 3 year SMA new; Description French: Codesoft Lite - PL Software Key Protection - 3 year SMA new |
|||
CS NW RFID 1 User USB 3 SMA AE Software |
|||
| 362926 | BRADY NV | Box of 1 Piece(s) | EUR 3759 |
|
Description: Description Dutch: Codesoft Network RFID 1 User USB Protection 3 year SMA; Description French: Codesoft Network RFID 1 User USB Protection 3 year SMA |
|||
CS NW RFID 1 User SWON 3 SMA AE Software |
|||
| 362924 | BRADY NV | Box of 1 Piece(s) | EUR 3633 |
|
Description: Description Dutch: Codesoft Network RFID 1 User Software Protection Online 3 year SMA; Description French: Codesoft Network RFID 1 User Software Protection Online 3 year SMA |
|||
CS NW RFID 1 User PLSW 3 SMA AE Software |
|||
| 362928 | BRADY NV | Box of 1 Piece(s) | EUR 3633 |
|
Description: Description Dutch: Codesoft Network RFID 1 User Platinum Software Key Protection 3 year SMA; Description French: Codesoft Network RFID 1 User Platinum Software Key Protection 3 year SMA |
|||
CS NW RFID 5 Users USB 3 SMA AE Software |
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| 362931 | BRADY NV | Box of 1 Piece(s) | EUR 6037.5 |
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Description: Description Dutch: Codesoft Network RFID 5 User USB Protection 3 year SMA; Description French: Codesoft Network RFID 5 User USB Protection 3 year SMA |
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CS NW RFID 5 Users SWON 3 SMA AE Software |
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| 362929 | BRADY NV | Box of 1 Piece(s) | EUR 5911.5 |
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Description: Description Dutch: Codesoft Network RFID 5 User Software Protection Online 3 year SMA; Description French: Codesoft Network RFID 5 User Software Protection Online 3 year SMA |
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CS NW RFID 5 Users PLSW 3 SMA AE Software |
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| 362933 | BRADY NV | Box of 1 Piece(s) | EUR 5911.5 |
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Description: Description Dutch: Codesoft Network RFID 5 User Platinum Software Key Protection 3 year SMA; Description French: Codesoft Network RFID 5 User Platinum Software Key Protection 3 year SMA |
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CS NW RFID 1 User 1 SMA AE Software |
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| 363086 | BRADY NV | Box of 1 Piece(s) | EUR 409.5 |
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Description: Description Dutch: Codesoft Network RFID 1 User-1 year SMA; Description French: Codesoft Network RFID 1 User-1 year SMA |
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CS NW RFID 5 Users 1 SMA AE Software |
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| 363088 | BRADY NV | Box of 1 Piece(s) | EUR 661.5 |
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Description: Description Dutch: Codesoft Network RFID 5 Users-1 year SMA; Description French: Codesoft Network RFID 5 Users-1 year SMA |
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CS Pro 3 THT-PLSW -3 year SMA new AE Software |
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| 196142 | BRADY NV | Box of 1 Piece(s) | EUR 1375.5 |
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Description: Description Dutch: Codesoft Pro 3 THT Printer - PL Software Key Protection - 3 year SMA new; Description French: Codesoft Pro 3 THT Printer - PL Software Key Protection - 3 year SMA new |
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CS RT NW RFID 5 Users USB 3 SMA AE Software |
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| 362960 | BRADY NV | Box of 1 Piece(s) | EUR 2814 |
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Description: Description Dutch: Codesoft Runtime Network RFID 5 User USB Protection 3 year SMA; Description French: Codesoft Runtime Network RFID 5 User USB Protection 3 year SMA |
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CS NW RFID VM 1 USER SWON 3 SMA AE Software |
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| 363218 | BRADY NV | Box of 1 Piece(s) | EUR 4788 |
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Description: Description Dutch: CODESOFT Network RFID 1 user - VMSoftware Protection Online3 year SMA; Description French: CODESOFT Network RFID 1 user - VMSoftware Protection Online3 year SMA |
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CS NW RFID VM 1 USER PLAT 3 SMA AE Software |
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| 363219 | BRADY NV | Box of 1 Piece(s) | EUR 4788 |
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Description: Description Dutch: CODESOFT Network RFID 1 user - VMPlatinum Software Key Protection3 year SMA; Description French: CODESOFT Network RFID 1 user - VMPlatinum Software Key Protection3 year SMA |
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CS NW RFID VM 5 USER SWON 3 SMA AE Software |
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| 363220 | BRADY NV | Box of 1 Piece(s) | EUR 7791 |
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Description: Description Dutch: CODESOFT Network RFID 5 users - VMSoftware Protection Online3 year SMA; Description French: CODESOFT Network RFID 5 users - VMSoftware Protection Online3 year SMA |
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CS NW RFID VM 5 USER PLAT 3 SMA AE Software |
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| 363221 | BRADY NV | Box of 1 Piece(s) | EUR 7791 |
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Description: Description Dutch: CODESOFT Network RFID 5 users - VMPlatinum Software Key Protection3 year SMA; Description French: CODESOFT Network RFID 5 users - VMPlatinum Software Key Protection3 year SMA |
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CS RT NW RFID 5 Users SWON 3 SMA AE Software |
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| 362958 | BRADY NV | Box of 1 Piece(s) | EUR 2688 |
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Description: Description Dutch: Codesoft Runtime Network RFID 5 User Software Protection Online 3 year SMA; Description French: Codesoft Runtime Network RFID 5 User Software Protection Online 3 year SMA |
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CS RT NW RFID 5 Users PLSW 3 SMA AE Software |
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| 362962 | BRADY NV | Box of 1 Piece(s) | EUR 2688 |
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Description: Description Dutch: Codesoft Runtime Network RFID 5 User Platinum Software Key Protection 3 year SMA; Description French: Codesoft Runtime Network RFID 5 User Platinum Software Key Protection 3 year SMA |
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CS RT NW RFID VM 5USER SWON 3 SMA AE Software |
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| 363224 | BRADY NV | Box of 1 Piece(s) | EUR 3538.5 |
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Description: Description Dutch: CODESOFT Runtime Network RFID 5 users - VMSoftware Protection Online3 year SMA; Description French: CODESOFT Runtime Network RFID 5 users - VMSoftware Protection Online3 year SMA |
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CS RT NW RFID VM 5USER PLAT 3 SMA AE Software |
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| 363225 | BRADY NV | Box of 1 Piece(s) | EUR 3538.5 |
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Description: Description Dutch: CODESOFT Runtime Network RFID 5 users - VMPlatinum Software Key Protection3 year SMA; Description French: CODESOFT Runtime Network RFID 5 users - VMPlatinum Software Key Protection3 year SMA |
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CS Lite-ECE-PLSW -3 year SMA new AE Software |
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| 196116 | BRADY NV | Box of 1 Piece(s) | EUR 441 |
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Description: Description Dutch: Codesoft Lite - ECE - PL Software Key Protection - 3 year SMA new; Description French: Codesoft Lite - ECE - PL Software Key Protection - 3 year SMA new |
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CS Pro 3 THT-PLSW -1 year SMA new AE Software |
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| 196145 | BRADY NV | Box of 1 Piece(s) | EUR 1081.5 |
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Description: Description Dutch: Codesoft Pro 3 THT Printer - PL Software Key Protection - 1 year SMA new; Description French: Codesoft Pro 3 THT Printer - PL Software Key Protection - 1 year SMA new |
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CS Pro 1 THT-PLSW -3 year SMA new AE Software |
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| 196159 | BRADY NV | Box of 1 Piece(s) | EUR 1102.5 |
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Description: Description Dutch: Codesoft Pro 1 THT Printer - PL Software Key Protection - 3 year SMA new; Description French: Codesoft Pro 1 THT Printer - PL Software Key Protection - 3 year SMA new |
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CS Lite-PLSW -1 year SMA new AE Software |
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| 196173 | BRADY NV | Box of 1 Piece(s) | EUR 651 |
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Description: Description Dutch: Codesoft Lite - PL Software Key Protection - 1 year SMA new; Description French: Codesoft Lite - PL Software Key Protection - 1 year SMA new |
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CS NW RFID 1 User USB 1 SMA AE Software |
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| 362864 | BRADY NV | Box of 1 Piece(s) | EUR 3055.5 |
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Description: Description Dutch: Codesoft Network RFID 1 User USB Protection 1 year SMA; Description French: Codesoft Network RFID 1 User USB Protection 1 year SMA |
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CS NW RFID 1 User SWON 1 SMA AE Software |
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| 362862 | BRADY NV | Box of 1 Piece(s) | EUR 2929.5 |
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Description: Description Dutch: Codesoft Network RFID 1 User Software Protection Online 1 year SMA; Description French: Codesoft Network RFID 1 User Software Protection Online 1 year SMA |
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CS NW RFID 1 User PLSW 1 SMA AE Software |
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| 362866 | BRADY NV | Box of 1 Piece(s) | EUR 2929.5 |
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Description: Description Dutch: Codesoft Network RFID 1 User Platinum Software Key Protection 1 year SMA; Description French: Codesoft Network RFID 1 User Platinum Software Key Protection 1 year SMA |
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CS NW RFID 5 Users USB 1 SMA AE Software |
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| 362869 | BRADY NV | Box of 1 Piece(s) | EUR 4903.5 |
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Description: Description Dutch: Codesoft Network RFID 5 User USB Protection 1 year SMA; Description French: Codesoft Network RFID 5 User USB Protection 1 year SMA |
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CS Pro 3 THT-ECE-1 year SMA-RENEW AE Software |
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| 196161 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
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Description: Description Dutch: Codesoft Pro 3 THT Printer - ECE - 1 year SMA - Renewal SMA Renewal; Description French: Codesoft Pro 3 THT Printer - ECE - 1 year SMA - Renewal SMA Renewal |
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CS NW RFID 5 Users SWON 1 SMA AE Software |
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| 362867 | BRADY NV | Box of 1 Piece(s) | EUR 4777.5 |
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Description: Description Dutch: Codesoft Network RFID 5 User Software Protection Online 1 year SMA; Description French: Codesoft Network RFID 5 User Software Protection Online 1 year SMA |
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CS NW RFID 5 Users PLSW 1 SMA AE Software |
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| 362871 | BRADY NV | Box of 1 Piece(s) | EUR 4777.5 |
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Description: Description Dutch: Codesoft Network RFID 5 User Platinum Software Key Protection 1 year SMA; Description French: Codesoft Network RFID 5 User Platinum Software Key Protection 1 year SMA |
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CS Pro 3 THT-ECE-PLSW -3 year SMA new AE Software |
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| 196186 | BRADY NV | Box of 1 Piece(s) | EUR 997.5 |
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Description: Description Dutch: Codesoft Pro 3 THT Printer - ECE - PL Software Key Protection - 3 year SMA new; Description French: Codesoft Pro 3 THT Printer - ECE - PL Software Key Protection - 3 year SMA new |
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CS NW RFID 1 user-Online SUBS New AE Software |
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| 196167 | BRADY NV | Box of 1 Piece(s) | EUR 1449 |
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Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
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ADD of 5 users for NW 5-3 year SMA AE Software |
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| 196114 | BRADY NV | Box of 1 Piece(s) | EUR 2688 |
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Description: Description Dutch: Addition of 5 users for Network 5 users - 3 year SMA Add-on; Description French: Addition of 5 users for Network 5 users - 3 year SMA Add-on |
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CS RT NW RFID 5 Users USB 1 SMA AE Software |
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| 362898 | BRADY NV | Box of 1 Piece(s) | EUR 2299.5 |
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Description: Description Dutch: Codesoft Runtime Network RFID 5 User USB Protection 1 year SMA; Description French: Codesoft Runtime Network RFID 5 User USB Protection 1 year SMA |
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CS Pro 1 THT-ECE-PLSW -3 year SMA new AE Software |
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| 196156 | BRADY NV | Box of 1 Piece(s) | EUR 787.5 |
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Description: Description Dutch: Codesoft Pro 1 THT Printer - ECE - PL Software Key Protection - 3 year SMA new; Description French: Codesoft Pro 1 THT Printer - ECE - PL Software Key Protection - 3 year SMA new |
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CS Pro 3 THT-ECE-PLSW -1 year SMA new AE Software |
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| 196164 | BRADY NV | Box of 1 Piece(s) | EUR 756 |
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Description: Description Dutch: Codesoft Pro 3 THT Printer - ECE - PL Software Key Protection - 1 year SMA new; Description French: Codesoft Pro 3 THT Printer - ECE - PL Software Key Protection - 1 year SMA new |
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CS RT NW RFID 5 Users SWON 1 SMA AE Software |
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| 362896 | BRADY NV | Box of 1 Piece(s) | EUR 2173.5 |
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Description: Description Dutch: Codesoft Runtime Network RFID 5 User Software Protection Online 1 year SMA; Description French: Codesoft Runtime Network RFID 5 User Software Protection Online 1 year SMA |
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CS RT NW RFID 5 Users PLSW 1 SMA AE Software |
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| 362900 | BRADY NV | Box of 1 Piece(s) | EUR 2173.5 |
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Description: Description Dutch: Codesoft Runtime Network RFID 5 User Platinum Software Key Protection 1 year SMA; Description French: Codesoft Runtime Network RFID 5 User Platinum Software Key Protection 1 year SMA |
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CS Lite-ECE-PLSW -1 year SMA new AE Software |
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| 196125 | BRADY NV | Box of 1 Piece(s) | EUR 325.5 |
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Description: Description Dutch: Codesoft Lite - ECE - PL Software Key Protection - 1 year SMA new; Description French: Codesoft Lite - ECE - PL Software Key Protection - 1 year SMA new |
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CS Pro 1 THT-PLSW -1 year SMA new AE Software |
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| 196180 | BRADY NV | Box of 1 Piece(s) | EUR 871.5 |
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Description: Description Dutch: Codesoft Pro 1 THT Printer - PL Software Key Protection - 1 year SMA new; Description French: Codesoft Pro 1 THT Printer - PL Software Key Protection - 1 year SMA new |
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CS Pro 1 THT -ECE-1 year SMA-RENEW AE Software |
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| 196090 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
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Description: Description Dutch: Codesoft Pro 1 THT Printer -ECE - 1 year SMA - Renewal SMA Renewal; Description French: Codesoft Pro 1 THT Printer -ECE - 1 year SMA - Renewal SMA Renewal |
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ADD of 5 users for RT NW 5-3 year SMA AE Software |
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| 196105 | BRADY NV | Box of 1 Piece(s) | EUR 2289 |
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Description: Description Dutch: Addition of 5 users for Runtime Network 5 users - 3 year SMA Add-on; Description French: Addition of 5 users for Runtime Network 5 users - 3 year SMA Add-on |
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CS RT RFID-VM-PL-RENEW VM SMA RENEW AE Software |
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| 196118 | BRADY NV | Box of 1 Piece(s) | EUR 546 |
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Description: Description Dutch: Codesoft Runtime RFID - VM - PL - Renewal VM Perpetual SMA Renewal; Description French: Codesoft Runtime RFID - VM - PL - Renewal VM Perpetual SMA Renewal |
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ADD of 5 users for NW 5-1 year SMA AE Software |
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| 196124 | BRADY NV | Box of 1 Piece(s) | EUR 2173.5 |
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Description: Description Dutch: Addition of 5 users for Network 5 users - 1 year SMA Add-on; Description French: Addition of 5 users for Network 5 users - 1 year SMA Add-on |
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CS Pro 1 THT-ECE-PLSW -1 year SMA new AE Software |
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| 196095 | BRADY NV | Box of 1 Piece(s) | EUR 598.5 |
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Description: Description Dutch: Codesoft Pro 1 THT Printer - ECE - PL Software Key Protection - 1 year SMA new; Description French: Codesoft Pro 1 THT Printer - ECE - PL Software Key Protection - 1 year SMA new |
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Particular actions of ATP and Tpm1.1(α) are decided throughout an in vitro incubation of rat cardiac tissue [12 day-old, 50% phosphorylated Tpm1.1(α)] with [32P]orthophosphate. The incorporation of an isotope into tropomyosin lags behind that of ATP by an element of roughly 10, indicating that switch is a relatively sluggish course of.