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Phosphorylation and Driver Mutations in PI3Kα and PTEN Autoinhibition

Phosphorylation and Driver Mutations in PI3Kα and PTEN Autoinhibition

Posted on December 10, 2020 by Christopher

PI3K and PTEN are the second and third most extremely mutated proteins in most cancers following solely p53. Their actions oppose one another. PI3K phosphorylates signaling lipid PIP2 to PIP3. PTEN dephosphorylates it again. Driver mutations in each proteins accrue PIP3. PIP3 recruits Akt and PDK1 to the membrane, selling cell cycle development. Right here we assessment phosphorylation occasions and mutations in autoinhibition in PI3K and PTEN from the structural standpoint. Our goal is to make clear how they management the autoinhibited states. In autoinhibition a section or a subunit of the protein occludes its purposeful website. Protein-protein interfaces are sometimes solely marginally steady, making them delicate to adjustments in situations in dwelling cells. Phosphorylation can stabilize or destabilize the interfaces. Driver mutations generally destabilize them.

In analogy to ‘passenger mutations’, we coin ‘passenger phosphorylation’ to emphasise that the presence of a phosphorylation recognition sequence brand doesn’t essentially indicate perform. Relatively, it could merely mirror a statistical incidence. In each PI3K and PTEN autoinhibiting phosphorylation occasions are noticed within the occluding ‘piece’. In PI3Kα the ‘piece’ is the p85α subunit. In PTEN it’s the C-terminal section. In each enzymes the stabilized interface covers the area that attaches to the membrane. Driver mutations that set off rotation of the occluding piece or its deletion immediate activation. Up to now, each enzymes lack particular, potent medication.

 

We focus on the implications of detailed structural and mechanistic perception into oncogenic activation and the way it can advance allosteric precision oncology. Many types of cardiac illness, together with coronary heart failure, current with insufficient protein high quality management (PQC). Pathological situations usually contain impaired removing of terminally misfolded proteins. This ends in the formation of huge protein aggregates, which additional scale back mobile viability and cardiac perform. Cardiomyocytes have an intricately collaborative PQC system to reduce mobile proteotoxicity.

 

Smad3 C-terminal phosphorylation website mutation attenuates the hepatoprotective impact of salvianolic acid B towards hepatocarcinogenesis

Smad3 phosphorylation is implicated in hepatic fibro-carcinogenesis. Furthermore, Smad3 phospho-isoform pSmad3L and pSmad3C are reversible and antagonistic, and the steadiness may shift from carcinogenesis to tumor-suppression. pSmad3C has lately assigned to carry out a preventative impact towards major liver damage. Salvianolic acid B (Sal B), a element derived from Salvia miltiorrhiza, is empirically used for hepatic illnesses. Our prior examine clarified that Sal B may delay hepatic fibrosis-carcinoma development by changing pSmad3L/3C in mice.
Nonetheless, the roles of Smad3 phospho-isoform conversion and antagonism within the anti-hepatocarcinogenic results of Sal B in pSmad3C- or/and pSmad3L-mutated mice/cells stay obscure. Presently, corresponding doses/concentrations of Sal B was co-administrated to pSmad3C+/- mutational mice/plasmids-transfected HepG2 cells. Notably, in vivo purposeful research revealed that pSmad3C mutation attenuates Sal B-induced ameliorative results on histopathological traits and decreased serological biomarkers, and potential mechanism entails attenuation of will increase in pSmad3C/p21 and reduces in pSmad3L/PAI-1/c-Myc expression.
Expectedly, in vitro outcomes confirmed that up-regulating pSmad3C enhances the inhibitory results on proliferation, migration and contributes to apoptosis accompanied by a shift of pSmad3L/PAI-1/c-Myc oncogenic to pSmad3C/p21 tumour-suppressive signalling; nonetheless, reverse results happen when upregulated pSmad3L. This examine is the primary to determine pSmad3C as a key goal by which Sal B prevents hepatocarcinogenesis.
 Phosphorylation and Driver Mutations in PI3Kα and PTEN Autoinhibition
Phosphorylation and Driver Mutations in PI3Kα and PTEN Autoinhibition

Additional Investigation into the Biochemical Results of Phosphorylation of Tropomyosin Tpm1.1(α). Serine-283 Is in Communication with the Midregion

The phosphorylated and unphosphorylated types of tropomyosin Tpm1.1(α) are ready from grownup rabbit coronary heart and in contrast biochemically. Electrophoresis confirms the excessive degree of enrichment of the chromatography fractions and is according to a single website of phosphorylation. Covalently certain phosphate teams at place 283 of Tpm1.1(α) enhance the speed of digestion at Leu-169, suggestive of a conformational rearrangement that extends to the midregion. Such a rearrangement, which is supported by ellipticity measurements between 25 and 42 °C, is according to a phosphorylation-mediated tightening of the interplay between varied myofilament parts. In a nonradioactive, co-sedimentation assay, phosphorylated Tpm1.1(α) shows a better affinity for F-actin in comparison with that of the unphosphorylated management .
Phosphorylation decreases the focus of skinny filaments required to achieve a half-maximal charge of launch of product from a pre-power stroke complicated [myosin-S1-2-deoxy-3-O-(N-methylanthraniloyl)ADP-Pi], as investigated by double-mixing stopped-flow fluorescence, suggestive of a change within the proportion of lively (turned on) and inactive (turned off) conformers, however comparable most charges of product launch are noticed with both sort of reconstituted skinny filament. Phosphorylated skinny filaments (pCa four and eight) show a better affinity for myosin-S1(ADP) versus the management state of affairs with out affecting isotherm steepness.

CUBE Programmed RFID Card

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EUR 349
Description: Mouse monoclonal SMA antibody

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Description: alpha-SMA antibody detects endogenous levels of alpha-SMA.

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EUR 920
Description: The α Skeletal Muslce Actin mouse monoclonal antibody can recognize endogenous α Skeletal Muslce Actin proteins.

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EUR 279
Description: A Rabbit Polyclonal antibody against ?-SMA from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

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Description: A Rabbit Polyclonal antibody against ?-SMA from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

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ES3783-100ul ELK Biotech 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against ?-SMA from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

?-SMA Polyclonal Antibody

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EUR 207
Description: A Rabbit Polyclonal antibody against ?-SMA from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

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ES3850-100ul ELK Biotech 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against ?-SMA from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

?-SMA Polyclonal Antibody

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Description: A Rabbit Polyclonal antibody against ?-SMA from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

?-SMA Polyclonal Antibody

ES3851-100ul ELK Biotech 100ul
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Description: A Rabbit Polyclonal antibody against ?-SMA from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

?-SMA Polyclonal Antibody

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Description: A Rabbit Polyclonal antibody against ?-SMA from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

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  • Immunogen information: Synthesized peptide derived from the N-terminal region of human ?-SMA
  • Applications tips:
Description: A polyclonal antibody for detection of Alpha-SMA from Human, Mouse, Rat. This Alpha-SMA antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human ?-SMA

Alpha-SMA Polyclonal Antibody

ABP52784-01ml Abbkine 0.1ml
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  • Immunogen information: Synthesized peptide derived from the N-terminal region of human ?-SMA
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Description: A polyclonal antibody for detection of Alpha-SMA from Human, Mouse, Rat. This Alpha-SMA antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human ?-SMA

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ABP52784-02ml Abbkine 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from the N-terminal region of human ?-SMA
  • Applications tips:
Description: A polyclonal antibody for detection of Alpha-SMA from Human, Mouse, Rat. This Alpha-SMA antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human ?-SMA

Alpha-SMA Polyclonal Antibody

ABP52851-003ml Abbkine 0.03ml
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  • Immunogen information: Synthesized peptide derived from the C-terminal region of human ?-SMA
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Description: A polyclonal antibody for detection of Alpha-SMA from Human, Mouse, Rat. This Alpha-SMA antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human ?-SMA

Alpha-SMA Polyclonal Antibody

ABP52851-01ml Abbkine 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from the C-terminal region of human ?-SMA
  • Applications tips:
Description: A polyclonal antibody for detection of Alpha-SMA from Human, Mouse, Rat. This Alpha-SMA antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human ?-SMA

Alpha-SMA Polyclonal Antibody

ABP52851-02ml Abbkine 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from the C-terminal region of human ?-SMA
  • Applications tips:
Description: A polyclonal antibody for detection of Alpha-SMA from Human, Mouse, Rat. This Alpha-SMA antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human ?-SMA

Alpha-SMA Polyclonal Antibody

ABP52852-003ml Abbkine 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from the Internal region of human ?-SMA
  • Applications tips:
Description: A polyclonal antibody for detection of Alpha-SMA from Human, Mouse, Rat. This Alpha-SMA antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ?-SMA

Alpha-SMA Polyclonal Antibody

ABP52852-01ml Abbkine 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from the Internal region of human ?-SMA
  • Applications tips:
Description: A polyclonal antibody for detection of Alpha-SMA from Human, Mouse, Rat. This Alpha-SMA antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ?-SMA

Alpha-SMA Polyclonal Antibody

ABP52852-02ml Abbkine 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from the Internal region of human ?-SMA
  • Applications tips:
Description: A polyclonal antibody for detection of Alpha-SMA from Human, Mouse, Rat. This Alpha-SMA antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ?-SMA

Alpha-SMA Polyclonal Antibody

ABP57522-003ml Abbkine 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from ?-SMA at AA range: 171-220
  • Applications tips:
Description: A polyclonal antibody for detection of Alpha-SMA from Human, Mouse, Rat. This Alpha-SMA antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from ?-SMA at AA range: 171-220

Alpha-SMA Polyclonal Antibody

ABP57522-01ml Abbkine 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from ?-SMA at AA range: 171-220
  • Applications tips:
Description: A polyclonal antibody for detection of Alpha-SMA from Human, Mouse, Rat. This Alpha-SMA antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from ?-SMA at AA range: 171-220

Alpha-SMA Polyclonal Antibody

ABP57522-02ml Abbkine 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from ?-SMA at AA range: 171-220
  • Applications tips:
Description: A polyclonal antibody for detection of Alpha-SMA from Human, Mouse, Rat. This Alpha-SMA antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from ?-SMA at AA range: 171-220

Alpha-SMA Monoclonal Antibody

ABM40185-003ml Abbkine 0.03ml
EUR 158
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of Alpha-SMA from Human, Mouse, Rat. This Alpha-SMA antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Alpha-SMA Monoclonal Antibody

ABM40185-01ml Abbkine 0.1ml
EUR 289
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of Alpha-SMA from Human, Mouse, Rat. This Alpha-SMA antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Alpha-SMA Monoclonal Antibody

ABM40185-02ml Abbkine 0.2ml
EUR 414
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of Alpha-SMA from Human, Mouse, Rat. This Alpha-SMA antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Alpha-SMA Monoclonal Antibody

ABM40186-003ml Abbkine 0.03ml
EUR 158
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of Alpha-SMA from Human, Mouse, Rat. This Alpha-SMA antibody is for WB, IF, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Alpha-SMA Monoclonal Antibody

ABM40186-01ml Abbkine 0.1ml
EUR 289
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of Alpha-SMA from Human, Mouse, Rat. This Alpha-SMA antibody is for WB, IF, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Alpha-SMA Monoclonal Antibody

ABM40186-02ml Abbkine 0.2ml
EUR 414
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of Alpha-SMA from Human, Mouse, Rat. This Alpha-SMA antibody is for WB, IF, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Anti- alpha-SMA Antibody

A03744 BosterBio 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for alpha-SMA Antibody (ACTC1) detection.tested for IHC-P, WB in Human, Mouse, Rat.

α-SMA Polyclonal Antibody

41550-100ul SAB 100ul
EUR 252

α-SMA Polyclonal Antibody

41550-50ul SAB 50ul
EUR 187

α-SMA Monoclonal Antibody

40482-100ul SAB 100ul
EUR 252

α-SMA Monoclonal Antibody

40482-50ul SAB 50ul
EUR 187

α-SMA Monoclonal Antibody

40495-100ul SAB 100ul
EUR 252

α-SMA Monoclonal Antibody

40495-50ul SAB 50ul
EUR 187

Anti-alpha-SMA antibody

STJ97381 St John's Laboratory 200 µl
EUR 197
Description: Mouse monoclonal to alpha-SMA.

Anti-alpha-SMA antibody

STJ97382 St John's Laboratory 200 µl
EUR 197
Description: alpha-SMA is a protein encoded by the ACTA2 gene which is approximately 42 kDa. alpha-SMA is localised to the cytoplasm and cytoskeleton. It is involved in the PAK pathway, VEGF pathway, fMLP pathway and Sertoli-Sertoli cell junction dynamics. This protein falls under the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. It is an alpha actin that is found in skeletal muscle. alpha-SMA is expressed in the muscle, lung, nervous system, intestine and pancreas. Mutations in the ACTA2 gene may result in Moyamoya disease. STJ97382 was developed from clone 6A12 and was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. The antibody detects endogenous alpha-SMA protein.

Anti-alpha-SMA antibody

STJ98628 St John's Laboratory 200 µl
EUR 197
Description: alpha-SMA is a protein encoded by the ACTA2 gene which is approximately 42 kDa. alpha-SMA is localised to the cytoplasm and cytoskeleton. It is involved in the PAK pathway, VEGF pathway, fMLP pathway and Sertoli-Sertoli cell junction dynamics. This protein falls under the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. This protein is an alpha actin that is found in skeletal muscle and is a major constituent of the contractile apparatus. alpha-SMA is expressed in the muscle, lung, nervous system, intestine and pancreas. Mutations in the ACTA2 gene may result in Moyamoya disease. STJ98628 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of alpha-SMA.

Anti-alpha-SMA antibody

STJ96418 St John's Laboratory 200 µl
EUR 197
Description: Rabbit polyclonal to alpha-SMA.

Anti-alpha-SMA antibody

STJ96485 St John's Laboratory 200 µl
EUR 197
Description: Rabbit polyclonal to alpha-SMA.

Anti-alpha-SMA antibody

STJ96486 St John's Laboratory 200 µl
EUR 197
Description: Rabbit polyclonal to alpha-SMA.

Sma I unit: 1500

YRSMA1 Yeastern Biotech 1 vial Ask for price

C-Series Mouse Inflammation Array Analysis Software

S02-AAM-INF-1 Neuromics CD
EUR 271

α-SMA Polyclonal Conjugated Antibody

C41550 SAB 100ul
EUR 397

Goat α-SMA ELISA Kit

EGTS0011 Abclonal 96Tests
EUR 521

Bovine α-SMA ELISA Kit

EBS0011 Abclonal 96Tests
EUR 521

Chicken α-SMA ELISA Kit

ECKS0011 Abclonal 96Tests
EUR 521

Anserini α-SMA ELISA Kit

EAS0011 Abclonal 96Tests
EUR 521

Canine α-SMA ELISA Kit

ECS0011 Abclonal 96Tests
EUR 521

Porcine α-SMA ELISA Kit

EPS0011 Abclonal 96Tests
EUR 521

Rat α-SMA ELISA Kit

ERS0011 Abclonal 96Tests
EUR 521

Sheep α-SMA ELISA Kit

ESS0011 Abclonal 96Tests
EUR 521

Rabbit α-SMA ELISA Kit

ERTS0011 Abclonal 96Tests
EUR 521

Monkey α-SMA ELISA Kit

EMKS0011 Abclonal 96Tests
EUR 521

Mouse α-SMA ELISA Kit

EMS0011 Abclonal 96Tests
EUR 521

Guinea Pig α-SMA ELISA Kit

EGS0011 Abclonal 96Tests
EUR 521

Anti-Actin, Smooth Muscle (SMA) antibody

STJ180001 St John's Laboratory 0.1 ml
EUR 212

Protection of Telomeres Protein 1 (POT1) Antibody

20-abx001265 Abbexa
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

Protection of Telomeres Protein 1 (POT1) Antibody

abx036150-100ug Abbexa 100 ug
EUR 391
  • Shipped within 5-10 working days.

Protection of Telomeres Protein 1 (POT1) Antibody

20-abx008212 Abbexa
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Protection Of Telomeres 1 Homolog (POT1) Antibody

20-abx174239 Abbexa
  • EUR 857.00
  • EUR 439.00
  • 1 mg
  • 200 ug
  • Please enquire.

Protection Of Telomeres 1 Homolog (POT1) Antibody

20-abx178139 Abbexa
  • EUR 1205.00
  • EUR 578.00
  • 1 mg
  • 200 ug
  • Please enquire.

Protection Of Telomeres 1 Homolog (POT1) Antibody

20-abx325024 Abbexa
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Protection of Telomeres Protein 1 (POT1) Antibody

abx217869-100ug Abbexa 100 ug
EUR 439
  • Shipped within 5-10 working days.

DNA Protection During Starvation Protein (dps) Antibody

20-abx319361 Abbexa
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Protection of Telomeres Protein 1 (POT1) Antibody

abx236645-100ug Abbexa 100 ug
EUR 509
  • Shipped within 5-12 working days.

Protection of Telomeres Protein 1 (POT1) Antibody

20-abx302412 Abbexa
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Human Protection of telomeres protein 1(POT1)

QY-E05316 Qayee Biotechnology 96T
EUR 361

IL-3 Interleukin-3 Human Recombinant Protein, His Tag

PROTP08700-3 BosterBio Regular: 50ug
EUR 317
Description: Interleukin-3 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 154 amino acids fragment (20-152) and having a total molecular mass of 17.3kDa and fused with a 20 aa N-terminal His tag. ;The IL3 His is purified by proprietary chromatographic techniques.

Anti-14-3-3 alpha + beta Rabbit Monoclonal Antibody

M02431-3 BosterBio 100ug/vial
EUR 397
Description: Rabbit Monoclonal 14-3-3 alpha + beta Antibody. Validated in Flow Cytometry, IP, IF, IHC, ICC, WB and tested in Human, Mouse, Rat.

Individual Reaction Mix 3

G065-3 ABM 200 reactions
EUR 167

3-D Life Thioglycerol

T10-3 Cellendes 180 µl
EUR 48

Human Smooth Muscle Antibody (SMA) ELISA Kit

abx053673-96tests Abbexa 96 tests
EUR 668
  • Shipped within 5-10 working days.

Alpha-Smooth Muscle Actin (alpha SMA) Antibody

abx020127-100ug Abbexa 100 ug
EUR 439
  • Shipped within 5-10 working days.

Human ?-Smooth muscle actin,?-SMA ELISA Kit

201-12-1209 SunredBio 96 tests
EUR 440
  • This alpha -Smooth muscle actin ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Sma I -HC unit: 1500, High Concentration

YRSMA1-HC Yeastern Biotech 1 vial Ask for price

Human Protection Of Telomeres 1 Homolog (POT1) Protein

20-abx654836 Abbexa
  • EUR 578.00
  • EUR 258.00
  • EUR 1720.00
  • EUR 690.00
  • EUR 425.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-15 working days.

Protection of Telomeres Protein 1 (POT1) Antibody (HRP)

20-abx317652 Abbexa
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Protection of Telomeres Protein 1 (POT1) Antibody (FITC)

20-abx317653 Abbexa
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Protection of Telomeres Protein 1 (POT1) Antibody (Biotin)

20-abx317654 Abbexa
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

DNA Protection During Starvation Protein (DPS) Antibody (HRP)

20-abx319362 Abbexa
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

DNA Protection During Starvation Protein (DPS) Antibody (FITC)

20-abx319363 Abbexa
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

DNA Protection During Starvation Protein (DPS) Antibody (Biotin)

20-abx319364 Abbexa
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Mycobacterium smegmatis DNA protection during starvation protein (dps)

1-CSB-EP314354MVW Cusabio
  • EUR 611.00
  • EUR 309.00
  • EUR 1827.00
  • EUR 939.00
  • EUR 1218.00
  • EUR 397.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 36.3 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Mycobacterium smegmatis DNA protection during starvation protein(dps) expressed in E.coli

Helicobacter pylori DNA protection during starvation protein (dps)

1-CSB-EP337381HUV Cusabio
  • EUR 611.00
  • EUR 309.00
  • EUR 1827.00
  • EUR 939.00
  • EUR 1218.00
  • EUR 397.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 32.9 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Helicobacter pylori DNA protection during starvation protein(dps) expressed in E.coli

TGF-b-3 Transforming Growth Factor-Beta 3 Human Recombinant Protein, Plant

PROTP10600-3 BosterBio Regular: 5ug
EUR 317
Description: TGFB3 Human Recombinant produced in plant is a disulfide-linked homodimeric, glycosylated, polypeptide chain containing 118 amino acids and having a molecular mass of 27.2kDa. ;The TGFB3 is fused to 6xHis tag at N-terminus and purified by standard chromatographic techniques.

Dr. P Kit-Solution 3

K2021010-3 Biochain 50 ml
EUR 133
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

3-D Life RGD Peptide

P10-3 Cellendes 3x 1 µmol
EUR 276

Recombinant Human MMP-3 Protein

PROTP08254-3 BosterBio 10ug
EUR 317
Description: Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-3 degrades fibronectin, laminin, collagens III, IV, and X, and cartilage proteoglycans. Recombinant human MMP-3 is a 42.8 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (378 amino acids).

3-D-Life SG-PVA

M81-3 Cellendes 3x 170 µl
EUR 148

3-D Life FG-PVA

M82-3 Cellendes 3x 170 µl
EUR 148

3-D Life SG-Dextran

M91-3 Cellendes 3x 170 µl
EUR 157

3-D Life FG-Dextran

M92-3 Cellendes 3x 170 µl
EUR 157

3-D Life PEG-Link

L50-3 Cellendes 3x 200 µl
EUR 94

3-D Life CD-Link

L60-3 Cellendes 3 x 200 µl
EUR 321

pLenti-CARM1 shRNA-3 Plasmid

PVTBAV03691-3 Lifescience Market 2 ug
EUR 356

pLenti-CTLA4 shRNA-3 Plasmid

PVTBAV05689-3 Lifescience Market 2 ug
EUR 356

pLenti-FOXM1 shRNA-3 Plasmid

PVTBAV08732-3 Lifescience Market 2 ug
EUR 356

pLenti-JUN shRNA-3 Plasmid

PVTBAV11741-3 Lifescience Market 2 ug
EUR 356

pLenti-LHX6 shRNA-3 Plasmid

PVTBAV12881-3 Lifescience Market 2 ug
EUR 356

pLenti-MAGEA3 shRNA-3 Plasmid

PVTBAV13661-3 Lifescience Market 2 ug
EUR 356

pLenti-RUNX3 shRNA-3 Plasmid

PVTBAV20583-3 Lifescience Market 2 ug
EUR 356

pLenti-Slc7a11 shRNA-3 Plasmid

PVTBAV21973-3 Lifescience Market 2 ug
EUR 356

pLenti-STAT3 shRNA-3 Plasmid

PVTBAV22921-3 Lifescience Market 2 ug
EUR 356

FSH (Human Follicle-stimulating hormone) ELISA test

3 Biobase 96T/Box Ask for price
  • Area of application: Hormone testing
Description: ELISA based test for quantitative detection of FSH (Human Follicle-stimulating hormone)

Anti-VEGF Receptor 3/FLT4 Antibody

A01276-3 BosterBio 100ug/vial
EUR 334

Caspase-3 Inhibitor Q-DEVD-OPh

1175-3 Biovision
EUR 533

3-D Life Scrambled RGD Peptide

P11-3 Cellendes 3x 1 µmol
EUR 276

Anti-active Caspase-3 Rabbit Monoclonal Antibody

M00334-3 BosterBio 100ug/vial
EUR 397
Description: Anti-active Caspase-3 Rabbit Monoclonal Antibody tested for IF, IHC, ICC, WB in Human
Particular actions of ATP and Tpm1.1(α) are decided throughout an in vitro incubation of rat cardiac tissue [12 day-old, 50% phosphorylated Tpm1.1(α)] with [32P]orthophosphate. The incorporation of an isotope into tropomyosin lags behind that of ATP by an element of roughly 10, indicating that switch is a relatively sluggish course of.

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Recent Posts

  • STAT3 Phosphorylation Inhibition for Treating Inflammation and New Bone Formation in Ankylosing Spondylitis
  • Phosphorylation and Driver Mutations in PI3Kα and PTEN Autoinhibition
  • HPV 16 E6/E7 Promote the Glucose Uptake of GLUT1 in Lung Cancer Through Downregulation of TXNIP Due to Inhibition of PTEN Phosphorylation
  • Regulation of an important glycolytic enzyme, pyruvate kinase, through phosphorylation in the larvae of a species of freeze tolerant insect, Eurosta solidaginis
  • A global analysis of low-complexity regions in the Trypanosoma brucei proteome reveals enrichment in the C-terminus of nucleic acid binding proteins providing potential targets of phosphorylation
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Recent Posts

  • STAT3 Phosphorylation Inhibition for Treating Inflammation and New Bone Formation in Ankylosing Spondylitis
  • Phosphorylation and Driver Mutations in PI3Kα and PTEN Autoinhibition
  • HPV 16 E6/E7 Promote the Glucose Uptake of GLUT1 in Lung Cancer Through Downregulation of TXNIP Due to Inhibition of PTEN Phosphorylation
  • Regulation of an important glycolytic enzyme, pyruvate kinase, through phosphorylation in the larvae of a species of freeze tolerant insect, Eurosta solidaginis
  • A global analysis of low-complexity regions in the Trypanosoma brucei proteome reveals enrichment in the C-terminus of nucleic acid binding proteins providing potential targets of phosphorylation
  • Myocardial Dysfunction in Cirrhotic Cardiomyopathy is Associated with Alterations of Phospholamban Phosphorylation and IL-6 Levels
  • Anti-Human Common beta chain
  • Glutathione Reductase Assay Kit
  • Culture Fluid for limit of detection determination
  • BK Virus Linearity control Panel

Categories

  • Antibodies
  • Assay Kits
  • Biology Cells
  • cDNA
  • Clia Kits
  • Culture Cells
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  • DNA Templates
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