Background: Low-complexity areas (LCRs) on proteins have attracted rising consideration not too long ago on account of their position within the meeting of membraneless organelles or granules by liquid-liquid section separation. A number of examples of such granules have been proven to sequester RNA and proteins in an inactive state, offering an vital mechanism for dynamic post-transcriptional gene regulation. In trypanosome parasites, post-transcriptional management overwhelmingly dominates gene regulation because of the organisation of their genome into polycistronic transcription items. The aim of the present research was to generate a considerably extra complete genome-wide survey of LCRs on trypanosome proteins than at present out there .
Strategies: Utilizing the Shannon’s entropy technique, supplied within the R bundle ‘entropy’, we recognized LCRs within the proteome of Trypanosoma brucei. Our evaluation predicts LCRs and their positional enrichment in distinct protein cohorts and superimposes on this a spread of post-translational modifications derived from out there experimental datasets.
Outcomes: Our outcomes spotlight the enrichment of LCRs within the C-terminal area of predicted nucleic acid binding proteins, these appearing as favoured websites for potential phosphorylation.
Conclusions: The post-translational modifications of LCRs, and particularly the phosphorylation occasions, may contribute to post-transcriptional gene expression management and the dynamics of protein concentrating on to membraneless organelles in kinetoplastid parasites.
Web site-Particular Phosphorylation of Histone H1.Four Is Related to Transcription Activation
Core histone variants, comparable to H2A.X and H3.3, serve specialised roles in chromatin processes that depend upon the genomic distributions and amino acid sequence variations of the variant proteins. Modifications of those variants alter interactions with different chromatin elements and thus the protein’s capabilities. These inferences add to the rising arsenal of proof towards the older generic view of these linker histones as redundant repressors.
Moreover, sure modifications of particular H1 variants can confer distinct roles. On the one hand, it has been reported that the phosphorylation of H1 ends in its launch from chromatin and the next transcription of HIV-1 genes. However, latest proof signifies that phosphorylated H1 could in truth be related to energetic promoters. This battle means that completely different H1 isoforms and modified variations of those variants aren’t redundant when collectively however could play distinct purposeful roles. Right here, we offer the primary genome-wide proof that when phosphorylated, the H1.Four variant stays related to energetic promoters and should even play a job in transcription activation. Utilizing novel, extremely particular antibodies, we generated the primary genome-wide view of the H1.Four isoform phosphorylated at serine 187 (pS187-H1.4) in estradiol-inducible MCF7 cells. We observe that pS187-H1.Four is enriched primarily on the transcription begin websites (TSSs) of genes activated by estradiol remedy and depleted from these which can be repressed. We additionally present that pS187-H1.
Four associates with ‘early estrogen response’ genes and stably interacts with RNAPII. Primarily based on the observations introduced right here, we suggest that phosphorylation at S187 by CDK9 represents an early occasion required for gene activation. This occasion may additionally be concerned within the launch of promoter-proximal polymerases to start elongation by interacting immediately with the polymerase or different components of the transcription equipment. Though we centered on estrogen-responsive genes, considering earlier proof of H1.4’s enrichment of promoters of pluripotency genes, and its involvement with rDNA activation, we suggest that H1.Four phosphorylation for gene activation could also be a extra world statement.
Photosensitive tyrosine analogues unravel site-dependent phosphorylation in TrkA initiated MAPK/ERK signaling
Tyrosine kinase A (TrkA) is a membrane receptor which, upon ligand binding, prompts a number of pathways together with MAPK/ERK signaling, implicated in a spectrum of human pathologies; thus, TrkA is an rising therapeutic goal in remedy of neuronal illnesses and most cancers. Nonetheless, mechanistic insights into TrKA signaling are missing on account of lack of site-dependent phosphorylation management.
Right here we engineer two light-sensitive tyrosine analogues, specifically p-azido-L-phenylalanine (AzF) and the caged-tyrosine (ONB), by means of amber codon suppression to optically manipulate the phosphorylation state of particular person intracellular tyrosines in TrkA. We establish TrkA-AzF and ONB mutants, which may activate the ERK pathway within the absence of NGF ligand binding by means of gentle management. Our outcomes not solely reveal how TrkA site-dependent phosphorylation controls the outlined signaling course of, but in addition lengthen the genetic code growth expertise to allow regulation of receptor-type kinase activation by optical management on the precision of a single phosphorylation website.
CODESOFT Lite - Renew AE Software |
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| 196527 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Lite - Renew AE Software |
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| 196579 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Lite - Renew AE Software |
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| 196581 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Lite - Renew AE Software |
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| 196584 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Pro 1THT - ECE - Renew AE Software |
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| 196522 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Pro 1THT - ECE - Renew AE Software |
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| 196531 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Pro 3THT - ECE - Renew AE Software |
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| 196536 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Pro 1THT - ECE - Renew AE Software |
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| 196537 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Pro 3THT - ECE - Renew AE Software |
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| 196541 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Pro 1THT - ECE - Renew AE Software |
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| 196542 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Pro 3THT - ECE - Renew AE Software |
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| 196552 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Pro 3THT - ECE - Renew AE Software |
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| 196554 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CS Lite-ECE-PLSW -1 year SMA new AE Software |
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| 196125 | BRADY NV | Box of 1 Piece(s) | EUR 325.5 |
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Description: Description Dutch: Codesoft Lite - ECE - PL Software Key Protection - 1 year SMA new; Description French: Codesoft Lite - ECE - PL Software Key Protection - 1 year SMA new |
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CS Lite-ECE-PLSW -3 year SMA new AE Software |
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| 196116 | BRADY NV | Box of 1 Piece(s) | EUR 441 |
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Description: Description Dutch: Codesoft Lite - ECE - PL Software Key Protection - 3 year SMA new; Description French: Codesoft Lite - ECE - PL Software Key Protection - 3 year SMA new |
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CS Lite-PLSW -1 year SMA new AE Software |
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| 196173 | BRADY NV | Box of 1 Piece(s) | EUR 651 |
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Description: Description Dutch: Codesoft Lite - PL Software Key Protection - 1 year SMA new; Description French: Codesoft Lite - PL Software Key Protection - 1 year SMA new |
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CODESOFT Pro 3THT - Renew AE Software |
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| 196525 | BRADY NV | Box of 1 Piece(s) | EUR 168 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Pro 3THT - Renew AE Software |
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| 196530 | BRADY NV | Box of 1 Piece(s) | EUR 168 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Pro 1THT - Renew AE Software |
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| 196558 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Pro 1THT - Renew AE Software |
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| 196566 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Pro 3THT - Renew AE Software |
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| 196576 | BRADY NV | Box of 1 Piece(s) | EUR 168 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Pro 1THT - Renew AE Software |
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| 196580 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Pro 1THT - Renew AE Software |
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| 196587 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Pro 3THT - Renew AE Software |
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| 196588 | BRADY NV | Box of 1 Piece(s) | EUR 168 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CS Lite-PLSW -3 year SMA new AE Software |
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| 196153 | BRADY NV | Box of 1 Piece(s) | EUR 850.5 |
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Description: Description Dutch: Codesoft Lite - PL Software Key Protection - 3 year SMA new; Description French: Codesoft Lite - PL Software Key Protection - 3 year SMA new |
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CODESOFT NW RFID 1 user - Renew AE Software |
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| 196534 | BRADY NV | Box of 1 Piece(s) | EUR 409.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT NW RFID 1 user - Renew AE Software |
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| 196543 | BRADY NV | Box of 1 Piece(s) | EUR 409.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT NW RFID 1 user - Renew AE Software |
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| 196565 | BRADY NV | Box of 1 Piece(s) | EUR 409.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT NW RFID 1 user - Renew AE Software |
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| 196585 | BRADY NV | Box of 1 Piece(s) | EUR 409.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Runtime RFID - Renew AE Software |
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| 196535 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Runtime RFID - Renew AE Software |
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| 196539 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Runtime RFID - Renew AE Software |
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| 196540 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Runtime RFID - Renew AE Software |
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| 196590 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Enterprise RFID - Renew AE Software |
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| 196559 | BRADY NV | Box of 1 Piece(s) | EUR 252 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Enterprise RFID - Renew AE Software |
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| 196561 | BRADY NV | Box of 1 Piece(s) | EUR 252 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Enterprise RFID - Renew AE Software |
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| 196563 | BRADY NV | Box of 1 Piece(s) | EUR 252 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Enterprise RFID - Renew AE Software |
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| 196583 | BRADY NV | Box of 1 Piece(s) | EUR 252 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT NW RFID 1 user - VM Renew AE Software |
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| 196597 | BRADY NV | Box of 1 Piece(s) | EUR 619.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT NW RFID 1 user - VM Renew AE Software |
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| 196598 | BRADY NV | Box of 1 Piece(s) | EUR 619.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT NW RFID 1 user - VM Renew AE Software |
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| 196599 | BRADY NV | Box of 1 Piece(s) | EUR 619.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Runtime RFID - VM Renew AE Software |
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| 196591 | BRADY NV | Box of 1 Piece(s) | EUR 157.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Runtime RFID - VM Renew AE Software |
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| 196592 | BRADY NV | Box of 1 Piece(s) | EUR 157.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Runtime RFID - VM Renew AE Software |
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| 196593 | BRADY NV | Box of 1 Piece(s) | EUR 157.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT NW RFID 5 users - Renew AE Software |
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| 196521 | BRADY NV | Box of 1 Piece(s) | EUR 661.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT NW RFID 5 users - Renew AE Software |
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| 196524 | BRADY NV | Box of 1 Piece(s) | EUR 661.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT NW RFID 5 users - Renew AE Software |
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| 196532 | BRADY NV | Box of 1 Piece(s) | EUR 661.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT NW RFID 5 users - Renew AE Software |
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| 196586 | BRADY NV | Box of 1 Piece(s) | EUR 661.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Enterprise RFID - VM Renew AE Software |
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| 196594 | BRADY NV | Box of 1 Piece(s) | EUR 388.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Enterprise RFID - VM Renew AE Software |
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| 196595 | BRADY NV | Box of 1 Piece(s) | EUR 388.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT Enterprise RFID - VM Renew AE Software |
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| 196596 | BRADY NV | Box of 1 Piece(s) | EUR 388.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT RT NW RFID 5 users - Renew AE Software |
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| 196553 | BRADY NV | Box of 1 Piece(s) | EUR 304.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT RT NW RFID 5 users - Renew AE Software |
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| 196556 | BRADY NV | Box of 1 Piece(s) | EUR 304.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT RT NW RFID 5 users - Renew AE Software |
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| 196557 | BRADY NV | Box of 1 Piece(s) | EUR 304.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CODESOFT RT NW RFID 5 users - Renew AE Software |
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| 196589 | BRADY NV | Box of 1 Piece(s) | EUR 304.5 |
|
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
|||
CODESOFT NW RFID 5 users - VM Renew AE Software |
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| 196600 | BRADY NV | Box of 1 Piece(s) | EUR 1008 |
|
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
|||
CODESOFT NW RFID 5 users - VM Renew AE Software |
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| 196601 | BRADY NV | Box of 1 Piece(s) | EUR 1008 |
|
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
|||
CODESOFT NW RFID 5 users - VM Renew AE Software |
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| 196602 | BRADY NV | Box of 1 Piece(s) | EUR 1008 |
|
Description: Description Dutch: Codesoft Labelontwerp Software; Description French: Logiciel de conception d'étiquettes Codesoft |
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CS Pro 1 THT -ECE-1 year SMA-RENEW AE Software |
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| 196090 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
|
Description: Description Dutch: Codesoft Pro 1 THT Printer -ECE - 1 year SMA - Renewal SMA Renewal; Description French: Codesoft Pro 1 THT Printer -ECE - 1 year SMA - Renewal SMA Renewal |
|||
CS Lite-ECE-Online SUBS New AE Software |
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| 196170 | BRADY NV | Box of 1 Piece(s) | EUR 231 |
|
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
|||
CS Pro 3 THT-ECE-1 year SMA-RENEW AE Software |
|||
| 196161 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
|
Description: Description Dutch: Codesoft Pro 3 THT Printer - ECE - 1 year SMA - Renewal SMA Renewal; Description French: Codesoft Pro 3 THT Printer - ECE - 1 year SMA - Renewal SMA Renewal |
|||
CS Pro 1 THT-ECE-PLSW -1 year SMA new AE Software |
|||
| 196095 | BRADY NV | Box of 1 Piece(s) | EUR 598.5 |
|
Description: Description Dutch: Codesoft Pro 1 THT Printer - ECE - PL Software Key Protection - 1 year SMA new; Description French: Codesoft Pro 1 THT Printer - ECE - PL Software Key Protection - 1 year SMA new |
|||
CS Pro 1 THT-ECE-PLSW -3 year SMA new AE Software |
|||
| 196156 | BRADY NV | Box of 1 Piece(s) | EUR 787.5 |
|
Description: Description Dutch: Codesoft Pro 1 THT Printer - ECE - PL Software Key Protection - 3 year SMA new; Description French: Codesoft Pro 1 THT Printer - ECE - PL Software Key Protection - 3 year SMA new |
|||
CS Pro 3 THT-ECE-PLSW -1 year SMA new AE Software |
|||
| 196164 | BRADY NV | Box of 1 Piece(s) | EUR 756 |
|
Description: Description Dutch: Codesoft Pro 3 THT Printer - ECE - PL Software Key Protection - 1 year SMA new; Description French: Codesoft Pro 3 THT Printer - ECE - PL Software Key Protection - 1 year SMA new |
|||
CS Pro 3 THT-ECE-PLSW -3 year SMA new AE Software |
|||
| 196186 | BRADY NV | Box of 1 Piece(s) | EUR 997.5 |
|
Description: Description Dutch: Codesoft Pro 3 THT Printer - ECE - PL Software Key Protection - 3 year SMA new; Description French: Codesoft Pro 3 THT Printer - ECE - PL Software Key Protection - 3 year SMA new |
|||
CS Lite-Online SUBS New AE Software |
|||
| 196181 | BRADY NV | Box of 1 Piece(s) | EUR 399 |
|
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
|||
CS Lite-ECE-PL SUBS New AE Software |
|||
| 196133 | BRADY NV | Box of 1 Piece(s) | EUR 231 |
|
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
|||
CS Lite-ECE-USB SUBS New AE Software |
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| 196115 | BRADY NV | Box of 1 Piece(s) | EUR 231 |
|
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
|||
CS Pro 1 THT-PLSW -1 year SMA new AE Software |
|||
| 196180 | BRADY NV | Box of 1 Piece(s) | EUR 871.5 |
|
Description: Description Dutch: Codesoft Pro 1 THT Printer - PL Software Key Protection - 1 year SMA new; Description French: Codesoft Pro 1 THT Printer - PL Software Key Protection - 1 year SMA new |
|||
CS Lite-ECE-Offline SUBS New AE Software |
|||
| 196094 | BRADY NV | Box of 1 Piece(s) | EUR 231 |
|
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
|||
CS Pro 3 THT-PLSW -1 year SMA new AE Software |
|||
| 196145 | BRADY NV | Box of 1 Piece(s) | EUR 1081.5 |
|
Description: Description Dutch: Codesoft Pro 3 THT Printer - PL Software Key Protection - 1 year SMA new; Description French: Codesoft Pro 3 THT Printer - PL Software Key Protection - 1 year SMA new |
|||
CS Pro 1 THT-PLSW -3 year SMA new AE Software |
|||
| 196159 | BRADY NV | Box of 1 Piece(s) | EUR 1102.5 |
|
Description: Description Dutch: Codesoft Pro 1 THT Printer - PL Software Key Protection - 3 year SMA new; Description French: Codesoft Pro 1 THT Printer - PL Software Key Protection - 3 year SMA new |
|||
ADD of 5 users for NW 5-1 year SMA AE Software |
|||
| 196124 | BRADY NV | Box of 1 Piece(s) | EUR 2173.5 |
|
Description: Description Dutch: Addition of 5 users for Network 5 users - 1 year SMA Add-on; Description French: Addition of 5 users for Network 5 users - 1 year SMA Add-on |
|||
CS Pro 3 THT-PLSW -3 year SMA new AE Software |
|||
| 196142 | BRADY NV | Box of 1 Piece(s) | EUR 1375.5 |
|
Description: Description Dutch: Codesoft Pro 3 THT Printer - PL Software Key Protection - 3 year SMA new; Description French: Codesoft Pro 3 THT Printer - PL Software Key Protection - 3 year SMA new |
|||
CS LT ECE USB 1 SMA AE Software |
|||
| 362860 | BRADY NV | Box of 1 Piece(s) | EUR 451.5 |
|
Description: Description Dutch: Codesoft Lite ECE USB Protection 1 year SMA; Description French: Codesoft Lite ECE USB Protection 1 year SMA |
|||
CS LT ECE SWON 1 SMA AE Software |
|||
| 362858 | BRADY NV | Box of 1 Piece(s) | EUR 325.5 |
|
Description: Description Dutch: Codesoft Lite ECE Software Protection Online 1 year SMA; Description French: Codesoft Lite ECE Software Protection Online 1 year SMA |
|||
ADD of 5 users for RT NW 5-1 year SMA AE Software |
|||
| 196168 | BRADY NV | Box of 1 Piece(s) | EUR 1848 |
|
Description: Description Dutch: Addition of 5 users for Runtime Network 5 users - 1 year SMA Add-on; Description French: Addition of 5 users for Runtime Network 5 users - 1 year SMA Add-on |
|||
CS NW RFID 5Online SUBS New AE Software |
|||
| 196112 | BRADY NV | Box of 1 Piece(s) | EUR 2320.5 |
|
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
|||
ADD of 5 users for NW 5-3 year SMA AE Software |
|||
| 196114 | BRADY NV | Box of 1 Piece(s) | EUR 2688 |
|
Description: Description Dutch: Addition of 5 users for Network 5 users - 3 year SMA Add-on; Description French: Addition of 5 users for Network 5 users - 3 year SMA Add-on |
|||
CS RT NW RFID 5Online SUBS New AE Software |
|||
| 196144 | BRADY NV | Box of 1 Piece(s) | EUR 1060.5 |
|
Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
|||
ADD of 5 users for RT NW 5-3 year SMA AE Software |
|||
| 196105 | BRADY NV | Box of 1 Piece(s) | EUR 2289 |
|
Description: Description Dutch: Addition of 5 users for Runtime Network 5 users - 3 year SMA Add-on; Description French: Addition of 5 users for Runtime Network 5 users - 3 year SMA Add-on |
|||
CS LT ECE USB 3 SMA AE Software |
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| 362922 | BRADY NV | Box of 1 Piece(s) | EUR 567 |
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Description: Description Dutch: Codesoft Lite ECE USB Protection 3 year SMA; Description French: Codesoft Lite ECE USB Protection 3 year SMA |
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CS LT ECE SWON 3 SMA AE Software |
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| 362920 | BRADY NV | Box of 1 Piece(s) | EUR 441 |
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Description: Description Dutch: Codesoft Lite ECE Software Protection Online 3 year SMA; Description French: Codesoft Lite ECE Software Protection Online 3 year SMA |
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CS PRO 1 THT PRTR ECE USB 1 SMA AE Software |
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| 362886 | BRADY NV | Box of 1 Piece(s) | EUR 724.5 |
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Description: Description Dutch: Codesoft Pro 1 THT Printer ECE USB Protection 1 year SMA; Description French: Codesoft Pro 1 THT Printer ECE USB Protection 1 year SMA |
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CS PRO 1 THT PRTR ECE SWON 1 SMA AE Software |
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| 362884 | BRADY NV | Box of 1 Piece(s) | EUR 598.5 |
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Description: Description Dutch: Codesoft Pro 1 THT Printer ECE Software Protection Online 1 year SMA; Description French: Codesoft Pro 1 THT Printer ECE Software Protection Online 1 year SMA |
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CS PRO 3 THT PRTR ECE USB 1 SMA AE Software |
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| 362894 | BRADY NV | Box of 1 Piece(s) | EUR 913.5 |
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Description: Description Dutch: Codesoft Pro 3 THT Printer ECE USB Protection 1 year SMA; Description French: Codesoft Pro 3 THT Printer ECE USB Protection 1 year SMA |
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CS PRO 1 THT PRTR ECE USB 3 SMA AE Software |
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| 362948 | BRADY NV | Box of 1 Piece(s) | EUR 913.5 |
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Description: Description Dutch: Codesoft Pro 1 THT Printer ECE USB Protection 3 year SMA; Description French: Codesoft Pro 1 THT Printer ECE USB Protection 3 year SMA |
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CS PRO 3 THT PRTR ECE SWON 1 SMA AE Software |
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| 362892 | BRADY NV | Box of 1 Piece(s) | EUR 756 |
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Description: Description Dutch: Codesoft Pro 3 THT Printer ECE Software Protection Online 1 year SMA; Description French: Codesoft Pro 3 THT Printer ECE Software Protection Online 1 year SMA |
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CS PRO 1 THT PRTR ECE SWON 3 SMA AE Software |
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| 362946 | BRADY NV | Box of 1 Piece(s) | EUR 787.5 |
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Description: Description Dutch: Codesoft Pro 1 THT Printer ECE Software Protection Online 3 year SMA; Description French: Codesoft Pro 1 THT Printer ECE Software Protection Online 3 year SMA |
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CS PRO 3 THT PRTR ECE USB 3 SMA AE Software |
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| 362956 | BRADY NV | Box of 1 Piece(s) | EUR 1123.5 |
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Description: Description Dutch: Codesoft Pro 3 THT Printer ECE USB Protection 3 year SMA; Description French: Codesoft Pro 3 THT Printer ECE USB Protection 3 year SMA |
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CS Lite-PL SUBS New AE Software |
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| 196101 | BRADY NV | Box of 1 Piece(s) | EUR 399 |
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Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
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CS PRO 3 THT PRTR ECE SWON 3 SMA AE Software |
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| 362954 | BRADY NV | Box of 1 Piece(s) | EUR 997.5 |
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Description: Description Dutch: Codesoft Pro 3 THT Printer ECE Software Protection Online 3 year SMA; Description French: Codesoft Pro 3 THT Printer ECE Software Protection Online 3 year SMA |
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CS Lite-USB SUBS New AE Software |
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| 196184 | BRADY NV | Box of 1 Piece(s) | EUR 399 |
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Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
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CS Pro 1THT-ECE-Online SUBS New AE Software |
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| 196129 | BRADY NV | Box of 1 Piece(s) | EUR 399 |
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Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
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CS Pro 3THT-ECE-Online SUBS New AE Software |
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| 196136 | BRADY NV | Box of 1 Piece(s) | EUR 493.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
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SAF-TRAIN-ONLINE AE Software |
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| 197652 | BRADY NV | Piece of 1 Piece(s) | EUR 281.19 |
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Description: Description Dutch: SafeTrak-opleiding eindgebruiker – 2 uur online; Description French: Formation des utilisateurs finaux de SafeTrak — 2 heures en ligne |
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CS LT USB 1 SMA AE Software |
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| 362856 | BRADY NV | Box of 1 Piece(s) | EUR 777 |
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Description: Description Dutch: Codesoft Lite USB Protection 1 year SMA; Description French: Codesoft Lite USB Protection 1 year SMA |
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CS RT RFID 1 SMA AE Software |
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| 363095 | BRADY NV | Box of 1 Piece(s) | EUR 115.5 |
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Description: Description Dutch: Codesoft Runtime RFID-1 year SMA; Description French: Codesoft Runtime RFID-1 year SMA |
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CS LT SWON 1 SMA AE Software |
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| 362854 | BRADY NV | Box of 1 Piece(s) | EUR 651 |
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Description: Description Dutch: Codesoft Lite Software Protection Online 1 year SMA; Description French: Codesoft Lite Software Protection Online 1 year SMA |
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CS ENT RFID 1 SMA AE Software |
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| 363081 | BRADY NV | Box of 1 Piece(s) | EUR 252 |
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Description: Description Dutch: Codesoft Enterprise RFID-1 year SMA; Description French: Codesoft Enterprise RFID-1 year SMA |
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CS PRO 1 THT PRTR 1 SMA AE Software |
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| 363091 | BRADY NV | Box of 1 Piece(s) | EUR 136.5 |
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Description: Description Dutch: Codesoft Pro 1 THT Printer-1 year SMA; Description French: Codesoft Pro 1 THT Printer-1 year SMA |
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CS RT RFID USB 1 SMA AE Software |
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| 362903 | BRADY NV | Box of 1 Piece(s) | EUR 882 |
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Description: Description Dutch: Codesoft Runtime RFID USB Protection 1 year SMA; Description French: Codesoft Runtime RFID USB Protection 1 year SMA |
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CS ENT RFID USB 1 SMA AE Software |
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| 362846 | BRADY NV | Box of 1 Piece(s) | EUR 1974 |
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Description: Description Dutch: Codesoft Enterprise RFID USB Protection 1 year SMA; Description French: Codesoft Enterprise RFID USB Protection 1 year SMA |
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CS RT RFID SWON 1 SMA AE Software |
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| 362901 | BRADY NV | Box of 1 Piece(s) | EUR 756 |
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Description: Description Dutch: Codesoft Runtime RFID Software Protection Online 1 year SMA; Description French: Codesoft Runtime RFID Software Protection Online 1 year SMA |
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CS RT RFID PLSW 1 SMA AE Software |
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| 362905 | BRADY NV | Box of 1 Piece(s) | EUR 756 |
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Description: Description Dutch: Codesoft Runtime RFID Platinum Software Key Protection 1 year SMA; Description French: Codesoft Runtime RFID Platinum Software Key Protection 1 year SMA |
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CS ENT RFID SWON 1 SMA AE Software |
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| 362844 | BRADY NV | Box of 1 Piece(s) | EUR 1848 |
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Description: Description Dutch: Codesoft Enterprise RFID Software Protection Online 1 year SMA; Description French: Codesoft Enterprise RFID Software Protection Online 1 year SMA |
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CS ENT RFID PLSW 1 SMA AE Software |
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| 362848 | BRADY NV | Box of 1 Piece(s) | EUR 1848 |
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Description: Description Dutch: Codesoft Enterprise RFID Platinum Software Key Protection 1 year SMA; Description French: Codesoft Enterprise RFID Platinum Software Key Protection 1 year SMA |
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CS NW RFID 1 User 1 SMA AE Software |
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| 363086 | BRADY NV | Box of 1 Piece(s) | EUR 409.5 |
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Description: Description Dutch: Codesoft Network RFID 1 User-1 year SMA; Description French: Codesoft Network RFID 1 User-1 year SMA |
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CS PRO 3 THT PRTR 1 SMA AE Software |
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| 363092 | BRADY NV | Box of 1 Piece(s) | EUR 168 |
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Description: Description Dutch: Codesoft Pro 3 THT Printer-1 year SMA; Description French: Codesoft Pro 3 THT Printer-1 year SMA |
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CS LT USB 3 SMA AE Software |
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| 362918 | BRADY NV | Box of 1 Piece(s) | EUR 976.5 |
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Description: Description Dutch: Codesoft Lite USB Protection 3 year SMA; Description French: Codesoft Lite USB Protection 3 year SMA |
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CS LT SWON 3 SMA AE Software |
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| 362916 | BRADY NV | Box of 1 Piece(s) | EUR 850.5 |
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Description: Description Dutch: Codesoft Lite Software Protection Online 3 year SMA; Description French: Codesoft Lite Software Protection Online 3 year SMA |
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CS PRO 1 THT PRTR USB 1 SMA AE Software |
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| 362882 | BRADY NV | Box of 1 Piece(s) | EUR 997.5 |
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Description: Description Dutch: Codesoft Pro 1 THT Printer USB Protection 1 year SMA; Description French: Codesoft Pro 1 THT Printer USB Protection 1 year SMA |
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CS PRO 1 THT PRTR SWON 1 SMA AE Software |
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| 362880 | BRADY NV | Box of 1 Piece(s) | EUR 871.5 |
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Description: Description Dutch: Codesoft Pro 1 THT Printer Software Protection Online 1 year SMA; Description French: Codesoft Pro 1 THT Printer Software Protection Online 1 year SMA |
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CS RT NW 5 Users 1 SMA AE Software |
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| 363093 | BRADY NV | Box of 1 Piece(s) | EUR 304.5 |
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Description: Description Dutch: Codesoft Runtime Network 5 users-1 year SMA; Description French: Codesoft Runtime Network 5 users-1 year SMA |
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CS Pro 3THT-Online SUBS New AE Software |
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| 196110 | BRADY NV | Box of 1 Piece(s) | EUR 588 |
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Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
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CS Pro 1THT-Online SUBS New AE Software |
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| 196183 | BRADY NV | Box of 1 Piece(s) | EUR 472.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
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CS NW RFID 5 Users 1 SMA AE Software |
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| 363088 | BRADY NV | Box of 1 Piece(s) | EUR 661.5 |
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Description: Description Dutch: Codesoft Network RFID 5 Users-1 year SMA; Description French: Codesoft Network RFID 5 Users-1 year SMA |
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CS NW RFID 1 User USB 1 SMA AE Software |
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| 362864 | BRADY NV | Box of 1 Piece(s) | EUR 3055.5 |
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Description: Description Dutch: Codesoft Network RFID 1 User USB Protection 1 year SMA; Description French: Codesoft Network RFID 1 User USB Protection 1 year SMA |
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CS PRO 3 THT PRTR USB 1 SMA AE Software |
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| 362890 | BRADY NV | Box of 1 Piece(s) | EUR 1207.5 |
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Description: Description Dutch: Codesoft Pro 3 THT Printer USB Protection 1 year SMA; Description French: Codesoft Pro 3 THT Printer USB Protection 1 year SMA |
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CS PRO 1 THT PRTR USB 3 SMA AE Software |
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| 362944 | BRADY NV | Box of 1 Piece(s) | EUR 1228.5 |
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Description: Description Dutch: Codesoft Pro 1 THT Printer USB Protection 3 year SMA; Description French: Codesoft Pro 1 THT Printer USB Protection 3 year SMA |
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CS NW RFID 1 User SWON 1 SMA AE Software |
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| 362862 | BRADY NV | Box of 1 Piece(s) | EUR 2929.5 |
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Description: Description Dutch: Codesoft Network RFID 1 User Software Protection Online 1 year SMA; Description French: Codesoft Network RFID 1 User Software Protection Online 1 year SMA |
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CS NW RFID 1 User PLSW 1 SMA AE Software |
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| 362866 | BRADY NV | Box of 1 Piece(s) | EUR 2929.5 |
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Description: Description Dutch: Codesoft Network RFID 1 User Platinum Software Key Protection 1 year SMA; Description French: Codesoft Network RFID 1 User Platinum Software Key Protection 1 year SMA |
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CS PRO 3 THT PRTR SWON 1 SMA AE Software |
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| 362888 | BRADY NV | Box of 1 Piece(s) | EUR 1081.5 |
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Description: Description Dutch: Codesoft Pro 3 THT Printer Software Protection Online 1 year SMA; Description French: Codesoft Pro 3 THT Printer Software Protection Online 1 year SMA |
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CS PRO 1 THT PRTR SWON 3 SMA AE Software |
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| 362942 | BRADY NV | Box of 1 Piece(s) | EUR 1102.5 |
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Description: Description Dutch: Codesoft Pro 1 THT Printer Software Protection Online 3 year SMA; Description French: Codesoft Pro 1 THT Printer Software Protection Online 3 year SMA |
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CS RT RFID-Online SUBS New AE Software |
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| 196127 | BRADY NV | Box of 1 Piece(s) | EUR 399 |
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Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
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CS RT RFID USB 3 SMA AE Software |
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| 362965 | BRADY NV | Box of 1 Piece(s) | EUR 1081.5 |
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Description: Description Dutch: Codesoft Runtime RFID USB Protection 3 year SMA; Description French: Codesoft Runtime RFID USB Protection 3 year SMA |
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CS ENT RFID-Online SUBS New AE Software |
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| 196152 | BRADY NV | Box of 1 Piece(s) | EUR 871.5 |
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Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
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CS ENT RFID USB 3 SMA AE Software |
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| 362908 | BRADY NV | Box of 1 Piece(s) | EUR 2394 |
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Description: Description Dutch: Codesoft Enterprise RFID USB Protection 3 year SMA; Description French: Codesoft Enterprise RFID USB Protection 3 year SMA |
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CS RT RFID SWON 3 SMA AE Software |
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| 362963 | BRADY NV | Box of 1 Piece(s) | EUR 955.5 |
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Description: Description Dutch: Codesoft Runtime RFID Software Protection Online 3 year SMA; Description French: Codesoft Runtime RFID Software Protection Online 3 year SMA |
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CS RT RFID PLSW 3 SMA AE Software |
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| 362967 | BRADY NV | Box of 1 Piece(s) | EUR 955.5 |
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Description: Description Dutch: Codesoft Runtime RFID Platinum Software Key Protection 3 year SMA; Description French: Codesoft Runtime RFID Platinum Software Key Protection 3 year SMA |
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CS ENT RFID SWON 3 SMA AE Software |
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| 362906 | BRADY NV | Box of 1 Piece(s) | EUR 2268 |
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Description: Description Dutch: Codesoft Enterprise RFID Software Protection Online 3 year SMA; Description French: Codesoft Enterprise RFID Software Protection Online 3 year SMA |
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CS ENT RFID PLSW 3 SMA AE Software |
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| 362910 | BRADY NV | Box of 1 Piece(s) | EUR 2268 |
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Description: Description Dutch: Codesoft Enterprise RFID Platinum Software Key Protection 3 year SMA; Description French: Codesoft Enterprise RFID Platinum Software Key Protection 3 year SMA |
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CS NW RFID 1 User USB 3 SMA AE Software |
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| 362926 | BRADY NV | Box of 1 Piece(s) | EUR 3759 |
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Description: Description Dutch: Codesoft Network RFID 1 User USB Protection 3 year SMA; Description French: Codesoft Network RFID 1 User USB Protection 3 year SMA |
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CS NW RFID 5 Users USB 1 SMA AE Software |
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| 362869 | BRADY NV | Box of 1 Piece(s) | EUR 4903.5 |
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Description: Description Dutch: Codesoft Network RFID 5 User USB Protection 1 year SMA; Description French: Codesoft Network RFID 5 User USB Protection 1 year SMA |
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CS NW RFID 1 User SWON 3 SMA AE Software |
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| 362924 | BRADY NV | Box of 1 Piece(s) | EUR 3633 |
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Description: Description Dutch: Codesoft Network RFID 1 User Software Protection Online 3 year SMA; Description French: Codesoft Network RFID 1 User Software Protection Online 3 year SMA |
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CS NW RFID 1 User PLSW 3 SMA AE Software |
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| 362928 | BRADY NV | Box of 1 Piece(s) | EUR 3633 |
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Description: Description Dutch: Codesoft Network RFID 1 User Platinum Software Key Protection 3 year SMA; Description French: Codesoft Network RFID 1 User Platinum Software Key Protection 3 year SMA |
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CS NW RFID 1 user-Online SUBS New AE Software |
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| 196167 | BRADY NV | Box of 1 Piece(s) | EUR 1449 |
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Description: Description Dutch: Codesoft Labelontwerp Software - Subscriptions; Description French: Logiciel de conception d'étiquettes Codesoft - Abonnement |
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CS NW RFID 5 Users SWON 1 SMA AE Software |
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| 362867 | BRADY NV | Box of 1 Piece(s) | EUR 4777.5 |
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Description: Description Dutch: Codesoft Network RFID 5 User Software Protection Online 1 year SMA; Description French: Codesoft Network RFID 5 User Software Protection Online 1 year SMA |
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It paves the best way for complete evaluation of kinase-associated pathways in addition to screening of compounds intervening in a site-directed phosphorylation pathway for focused remedy. Intermittent hypoxia (IH), a most important attribute of obstructive sleep apnea (OSA) syndrome, has been often known as a dominant explanation for OSA-related endothelial dysfunction and hypertension. Nonetheless, the underlying mechanism nonetheless stays unclear. Extracellular vesicles (EVs), small vesicles secreted by varied cells, may be absorbed by endothelial cells after which affect vascular operate. The goal of this analysis is to make clear whether or not and the way EVs shedding from purple blood cells (RBCs) are concerned in IH-induced endothelial dysfunction.